{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Huang L"],"pubmed_abstract":["<h4>Introduction</h4>Current targeted pulmonary arterial hypertension (PAH) therapies have improved lung hemodynamics, cardiac function, and quality of life; however, none of these have reversed the ongoing remodeling of blood vessels. Considering notopterol, a linear furocoumarin extracted from the root of traditional Chinese medicine Qiang-Huo (<i>Notopterygium incisum</i>), had shown the antiproliferative and anti-inflammatory properties in previous studies, we hypothesized that it could play a role in ameliorating PAH.<h4>Methods</h4><i>In vivo</i>, we conducted monocrotaline (MCT) induced PAH rats and treated them with notopterol for 3 weeks. Then, the rats were examined by echocardiography and RV catheterization. The heart and lung specimens were harvested for the detection of gross "],"journal":["Frontiers in cardiovascular medicine"],"pagination":["859422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9203832"],"repository":["biostudies-literature"],"pubmed_title":["Notopterol Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat."],"pmcid":["PMC9203832"],"pubmed_authors":["Li H","Gan S","Wu Z","Huang S","Wang S","Luo L","Fu G","Zou P","Chen G","Liu Q","Huang L"],"additional_accession":[]},"is_claimable":false,"name":"Notopterol Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat.","description":"<h4>Introduction</h4>Current targeted pulmonary arterial hypertension (PAH) therapies have improved lung hemodynamics, cardiac function, and quality of life; however, none of these have reversed the ongoing remodeling of blood vessels. Considering notopterol, a linear furocoumarin extracted from the root of traditional Chinese medicine Qiang-Huo (<i>Notopterygium incisum</i>), had shown the antiproliferative and anti-inflammatory properties in previous studies, we hypothesized that it could play a role in ameliorating PAH.<h4>Methods</h4><i>In vivo</i>, we conducted monocrotaline (MCT) induced PAH rats and treated them with notopterol for 3 weeks. Then, the rats were examined by echocardiography and RV catheterization. The heart and lung specimens were harvested for the detection of gross ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T03:06:16.423Z","creation":"2025-02-19T05:06:12.773Z"},"accession":"S-EPMC9203832","cross_references":{"pubmed":["35722110"],"doi":["10.3389/fcvm.2022.859422"]}}