biostudies-literatureUnknown9Huang L<h4>Introduction</h4>Current targeted pulmonary arterial hypertension (PAH) therapies have improved lung hemodynamics, cardiac function, and quality of life; however, none of these have reversed the ongoing remodeling of blood vessels. Considering notopterol, a linear furocoumarin extracted from the root of traditional Chinese medicine Qiang-Huo (<i>Notopterygium incisum</i>), had shown the antiproliferative and anti-inflammatory properties in previous studies, we hypothesized that it could play a role in ameliorating PAH.<h4>Methods</h4><i>In vivo</i>, we conducted monocrotaline (MCT) induced PAH rats and treated them with notopterol for 3 weeks. Then, the rats were examined by echocardiography and RV catheterization. The heart and lung specimens were harvested for the detection of gross Frontiers in cardiovascular medicine859422https://www.ebi.ac.uk/biostudies/studies/S-EPMC9203832biostudies-literatureNotopterol Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat.PMC9203832Li HGan SWu ZHuang SWang SLuo LFu GZou PChen GLiu QHuang LfalseNotopterol Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat.<h4>Introduction</h4>Current targeted pulmonary arterial hypertension (PAH) therapies have improved lung hemodynamics, cardiac function, and quality of life; however, none of these have reversed the ongoing remodeling of blood vessels. Considering notopterol, a linear furocoumarin extracted from the root of traditional Chinese medicine Qiang-Huo (<i>Notopterygium incisum</i>), had shown the antiproliferative and anti-inflammatory properties in previous studies, we hypothesized that it could play a role in ameliorating PAH.<h4>Methods</h4><i>In vivo</i>, we conducted monocrotaline (MCT) induced PAH rats and treated them with notopterol for 3 weeks. Then, the rats were examined by echocardiography and RV catheterization. The heart and lung specimens were harvested for the detection of gross 2022-01-01T00:00:00Z20222025-04-04T03:06:16.423Z2025-02-19T05:06:12.773ZS-EPMC92038323572211010.3389/fcvm.2022.859422