{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["328(2)"],"submitter":["Ramnarayan P"],"pubmed_abstract":["<h4>Importance</h4>The optimal first-line mode of noninvasive respiratory support for acutely ill children is not known.<h4>Objective</h4>To evaluate the noninferiority of high-flow nasal cannula therapy (HFNC) as the first-line mode of noninvasive respiratory support for acute illness, compared with continuous positive airway pressure (CPAP), for time to liberation from all forms of respiratory support.<h4>Design, setting, and participants</h4>Pragmatic, multicenter, randomized noninferiority clinical trial conducted in 24 pediatric critical care units in the United Kingdom among 600 acutely ill children aged 0 to 15 years who were clinically assessed to require noninvasive respiratory support, recruited between August 2019 and November 2021, with last follow-up completed in March 2022.<h"],"journal":["JAMA"],"pagination":["162-172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9204623"],"repository":["biostudies-literature"],"pubmed_title":["Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial."],"pmcid":["PMC9204623"],"pubmed_authors":["Feltbower RG","Silvestre C","Shah S","Ray S","Thorn N","Alcantara Gemmar L","James M","Tous Sampol L","Toko R","Taylor H","Samm K","Patel R","Prince N","Collier H","Pask D","Milla G","FIRST-ABC Step-Up RCT Investigators and the Paediatric Critical Care Society Study Group","Patel K","Sadique Z","Parslow R","Shetty N","Mackerness C","Bowes SE","Cook A","Lester J","White DK","Howlett A","Rowan KM","Adele S","Saikia B","Peters MJ","Aramburo A","Ros Foguet M","Saull M","Mellish C","VanDijke M","Miller L","Bunni L","Pereira Tomas AL","Scott JR","Bowdler-Hayes M","Sukhani S","Richards-Belle A","Jones G","Fraser LJ","Mason G","Thomas K","Hamilton M","Donnelly K","Oruganti S","Mayer AT","Mouncey PR","Bowerman A","Inwald D","O'Toole S","Fazackerley H","Caro IC","Dodge L","Khatun T","Ravindranathan B","Mahoney K","Au C","Tume LN","Bridges KE","Sprinckmoller S","Bryant J","Raeside H","Murad A","Sarfatti A","Sheedy S","Edmonds N","Drikite L","Claydon R","Belfield H","Mitting RB","Ramnarayan P","Neshat S","Orzechowska I","Carungcong J","Gomes de Queiroz J","Davis P","Richmond V","Coutts H","Peters S","Nundlall K","Pathan N","Meghari H","Morris KP","Laura O","Jennings C","Verhulst L","Evans A","Mustafa SK","Laura R","Darnell SE","Daggert SE","Saxton M","Daubney ES","Hutchings F","Kerry H","Davis PJ","Pappachan JV","Mulgrew K","Coy K","Dawn J","Norman L","Tagliavini E","Kashyap AS","Koelewyn A","Tan JC","Khalid N","Sherris L","Marshall R","Rohit S","Barton S","Beech E","Zammit V","Armstrong DK","Darnell R","Harrison DA","Grieve R","Sonia A","Deep A","Maccacari E","Oliver Z","O'Neill Gutierrez L","Smith E","Klonin H","Anderson L","Piper I","Samson-Fessale P","Edelman JR"],"additional_accession":[]},"is_claimable":false,"name":"Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial.","description":"<h4>Importance</h4>The optimal first-line mode of noninvasive respiratory support for acutely ill children is not known.<h4>Objective</h4>To evaluate the noninferiority of high-flow nasal cannula therapy (HFNC) as the first-line mode of noninvasive respiratory support for acute illness, compared with continuous positive airway pressure (CPAP), for time to liberation from all forms of respiratory support.<h4>Design, setting, and participants</h4>Pragmatic, multicenter, randomized noninferiority clinical trial conducted in 24 pediatric critical care units in the United Kingdom among 600 acutely ill children aged 0 to 15 years who were clinically assessed to require noninvasive respiratory support, recruited between August 2019 and November 2021, with last follow-up completed in March 2022.<h","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-29T11:08:50.326Z","creation":"2025-04-06T19:49:09.496Z"},"accession":"S-EPMC9204623","cross_references":{"pubmed":["35707984"],"doi":["10.1001/jama.2022.9615"]}}