biostudies-literatureUnknown16Rose JKExposure to alcohol causes deficits in long-term memory formation across species. Using a long-term habituation memory assay in <i>Caenorhabditis elegans</i>, the effects of ethanol on long-term memory (> 24 h) for habituation were investigated. An impairment in long-term memory was observed when animals were trained in the presence of ethanol. Cues of internal state or training context during testing did not restore memory. Ethanol exposure during training also interfered with the downregulation of AMPA/KA-type glutamate receptor subunit (GLR-1) punctal expression previously associated with long-term memory for habituation in <i>C. elegans</i>. Interestingly, ethanol exposure alone had the opposite effect, increasing GLR-1::GFP punctal expression. Worms with a mutation in the <i>C. eleganFrontiers in behavioral neuroscience908630https://www.ebi.ac.uk/biostudies/studies/S-EPMC9204643biostudies-literatureNeuroligin Plays a Role in Ethanol-Induced Disruption of Memory and Corresponding Modulation of Glutamate Receptor Expression.PMC9204643Butterfield MLiang JRose JKLin CHSParvand MRankin CHfalseNeuroligin Plays a Role in Ethanol-Induced Disruption of Memory and Corresponding Modulation of Glutamate Receptor Expression.Exposure to alcohol causes deficits in long-term memory formation across species. Using a long-term habituation memory assay in <i>Caenorhabditis elegans</i>, the effects of ethanol on long-term memory (> 24 h) for habituation were investigated. An impairment in long-term memory was observed when animals were trained in the presence of ethanol. Cues of internal state or training context during testing did not restore memory. Ethanol exposure during training also interfered with the downregulation of AMPA/KA-type glutamate receptor subunit (GLR-1) punctal expression previously associated with long-term memory for habituation in <i>C. elegans</i>. Interestingly, ethanol exposure alone had the opposite effect, increasing GLR-1::GFP punctal expression. Worms with a mutation in the <i>C. elegan2022-01-01T00:00:00Z20222025-04-19T17:46:29.997Z2024-11-20T15:54:47.294ZS-EPMC92046433572219010.3389/fnbeh.2022.908630