{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(7)"],"submitter":["Pontes G"],"pubmed_abstract":["Salts are essential nutrients required for many physiological processes, and accordingly, their composition and concentration are tightly regulated. Taste is the ultimate sensory modality involved in resource quality assessment, resulting in acceptance or rejection. Here we found that high salt concentrations elicit feeding avoidance in the blood-sucking bug <i>Rhodnius prolixus</i> and elucidate the molecular and neurophysiological mechanisms involved. We found that high-salt avoidance is mediated by a salt-sensitive antennal gustatory receptor neuron (GRN). Using RNAi, we demonstrate that this process requires two amiloride-sensitive pickpocket channels (PPKs; <i>Rpro</i> <i>PPK014276</i> and <i>Rpro</i> <i>PPK28</i>) expressed within these cells. We found that antennal GRNs project to t"],"journal":["iScience"],"pagination":["104502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9204723"],"repository":["biostudies-literature"],"pubmed_title":["Molecular and functional basis of high-salt avoidance in a blood-sucking insect."],"pmcid":["PMC9204723"],"pubmed_authors":["Pontes G","Beron de Astrada M","Barrozo RB","Latorre-Estivalis JM","Gutierrez ML","Lorenzo MG","Cano A"],"additional_accession":[]},"is_claimable":false,"name":"Molecular and functional basis of high-salt avoidance in a blood-sucking insect.","description":"Salts are essential nutrients required for many physiological processes, and accordingly, their composition and concentration are tightly regulated. Taste is the ultimate sensory modality involved in resource quality assessment, resulting in acceptance or rejection. Here we found that high salt concentrations elicit feeding avoidance in the blood-sucking bug <i>Rhodnius prolixus</i> and elucidate the molecular and neurophysiological mechanisms involved. We found that high-salt avoidance is mediated by a salt-sensitive antennal gustatory receptor neuron (GRN). Using RNAi, we demonstrate that this process requires two amiloride-sensitive pickpocket channels (PPKs; <i>Rpro</i> <i>PPK014276</i> and <i>Rpro</i> <i>PPK28</i>) expressed within these cells. We found that antennal GRNs project to t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-10T00:58:08.781Z","creation":"2025-04-07T01:56:02.451Z"},"accession":"S-EPMC9204723","cross_references":{"pubmed":["35720264"],"doi":["10.1016/j.isci.2022.104502"]}}