{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Palomer E"],"funding":["Alzheimers Research UK","Alzheimer&apos;s Research UK (ARUK)","Alzheimer's Society","Alzheimer&amp;apos;s Research UK"],"pagination":["3024-3033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9205772"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(7)"],"pubmed_abstract":["Growing evidence supports a role for deficient Wnt signalling in Alzheimer's disease (AD). First, the Wnt antagonist DKK1 is elevated in AD brains and is required for amyloid-β-induced synapse loss. Second, LRP6 Wnt co-receptor is required for synapse integrity and three variants of this receptor are linked to late-onset AD. However, the expression/role of other Wnt signalling components remain poorly explored in AD. Wnt receptors Frizzled1 (Fzd1), Fzd5, Fzd7 and Fzd9 are of interest due to their role in synapse formation/plasticity. Our analyses showed reduced FZD1 and FZD7 mRNA levels in the hippocampus of human early AD stages and in the hAPP<sup>NLGF/NLGF</sup> mouse model. This transcriptional downregulation was accompanied by reduced levels of the pro-transcriptional histone mark H4K"],"journal":["Molecular psychiatry"],"pubmed_title":["Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters."],"pmcid":["PMC9205772"],"funding_grant_id":["ARUK-2018DDI-UCL","AS-PG-17-006","ARUK-PG2018A-002"],"pubmed_authors":["Martin-Flores N","Whiting P","Vaher K","Saito T","Palomer E","Pascual-Vargas P","Salinas PC","Saido TC","Jolly S","Podpolny M","Teo S","Benvegnu S"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.","description":"Growing evidence supports a role for deficient Wnt signalling in Alzheimer's disease (AD). First, the Wnt antagonist DKK1 is elevated in AD brains and is required for amyloid-β-induced synapse loss. Second, LRP6 Wnt co-receptor is required for synapse integrity and three variants of this receptor are linked to late-onset AD. However, the expression/role of other Wnt signalling components remain poorly explored in AD. Wnt receptors Frizzled1 (Fzd1), Fzd5, Fzd7 and Fzd9 are of interest due to their role in synapse formation/plasticity. Our analyses showed reduced FZD1 and FZD7 mRNA levels in the hippocampus of human early AD stages and in the hAPP<sup>NLGF/NLGF</sup> mouse model. This transcriptional downregulation was accompanied by reduced levels of the pro-transcriptional histone mark H4K","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-22T21:09:16.18Z","creation":"2024-12-04T10:10:12.337Z"},"accession":"S-EPMC9205772","cross_references":{"pubmed":["35296808"],"doi":["10.1038/s41380-022-01492-z"]}}