biostudies-literatureMorrow AJBritish Heart FoundationMedical Research CouncilChief Scientist Office1303-1313https://www.ebi.ac.uk/biostudies/studies/S-EPMC9205780biostudies-literatureUnknown28(6)The pathophysiology and trajectory of post-Coronavirus Disease 2019 (COVID-19) syndrome is uncertain. To clarify multisystem involvement, we undertook a prospective cohort study including patients who had been hospitalized with COVID-19 (ClinicalTrials.gov ID NCT04403607 ). Serial blood biomarkers, digital electrocardiography and patient-reported outcome measures were obtained in-hospital and at 28-60 days post-discharge when multisystem imaging using chest computed tomography with pulmonary and coronary angiography and cardio-renal magnetic resonance imaging was also obtained. Longer-term clinical outcomes were assessed using electronic health records. Compared to controls (n = 29), at 28-60 days post-discharge, people with COVID-19 (n = 159; mean age, 55 years; 43% female) had persistingNature medicineA multisystem, cardio-renal investigation of post-COVID-19 illness.PMC9205780311300MC_PC_19026RE/18/6134217Brown ARankin AJMorrow AJMcGinley CDougherty ALang NNMcConnachie ADobbin SJHCISCO-19 ConsortiumHall Barrientos PGrieve DRobertson KEWatkins SMcIntosh AGibson VBTouyz RMGilmour LBlyth KGFallon KBerry CHo ABulluck HLowe DJHopkins TBriscoe MSykes RCarrick DMacfarlane PWChurch CMark PBMcGeoch RWelsh PSavage FNordin SBasu NTynan NRyan NDymock LSiebert SLennie VWeir RAWeeden SMcLennan ESattar NGillespie LFindlay IStobo DCorcoran DAllwood-Spiers SMcKee CButler ERoditi GWoodward RVeldtman GMayne KJBagot CMcInnes IBBayes HKPayne AMangion KLees JSKamdar AWereski RfalseA multisystem, cardio-renal investigation of post-COVID-19 illness.The pathophysiology and trajectory of post-Coronavirus Disease 2019 (COVID-19) syndrome is uncertain. To clarify multisystem involvement, we undertook a prospective cohort study including patients who had been hospitalized with COVID-19 (ClinicalTrials.gov ID NCT04403607 ). Serial blood biomarkers, digital electrocardiography and patient-reported outcome measures were obtained in-hospital and at 28-60 days post-discharge when multisystem imaging using chest computed tomography with pulmonary and coronary angiography and cardio-renal magnetic resonance imaging was also obtained. Longer-term clinical outcomes were assessed using electronic health records. Compared to controls (n = 29), at 28-60 days post-discharge, people with COVID-19 (n = 159; mean age, 55 years; 43% female) had persisting2022-01-01T00:00:00Z2022 Jun2026-05-10T01:41:14.245Z2025-02-19T02:57:49.435ZS-EPMC92057803560655110.1038/s41591-022-01837-9