biostudies-literatureUnknown13Huang S<h4>Aim</h4>This systematic review and meta-analysis was performed to assess the effect of <i>Viola odorata</i> (<i>V. odorata</i>) extract in the treatment of insomnia.<h4>Methods</h4>PubMed, EMBASE, and Cochrane Library databases, as well as references of related articles, were searched. Finally, four articles with five clinical trials including 224 patients were included in the analysis.<h4>Results</h4>The obtained results indicated a greater improvement in total PSQI scores (MD,-4.67; <i>P</i> = 0.0002), subjective sleep quality score (MD,-0.91; <i>P</i> = 0.003), sleep duration score (MD,-0.77; <i>P</i> < 0.00001), and ISI score (MD,-6.30; <i>P</i> = 0.009) in the Viola extract group compared with the placebo group. However, the Viola extract group did not significantly differ in sleeFrontiers in neurology730311https://www.ebi.ac.uk/biostudies/studies/S-EPMC9207380biostudies-literatureThe Efficacy of <i>V. odorata</i> Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis.PMC9207380Huang SZhang JLiang ZHuang QZhou ZZhan YfalseThe Efficacy of <i>V. odorata</i> Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis.<h4>Aim</h4>This systematic review and meta-analysis was performed to assess the effect of <i>Viola odorata</i> (<i>V. odorata</i>) extract in the treatment of insomnia.<h4>Methods</h4>PubMed, EMBASE, and Cochrane Library databases, as well as references of related articles, were searched. Finally, four articles with five clinical trials including 224 patients were included in the analysis.<h4>Results</h4>The obtained results indicated a greater improvement in total PSQI scores (MD,-4.67; <i>P</i> = 0.0002), subjective sleep quality score (MD,-0.91; <i>P</i> = 0.003), sleep duration score (MD,-0.77; <i>P</i> < 0.00001), and ISI score (MD,-6.30; <i>P</i> = 0.009) in the Viola extract group compared with the placebo group. However, the Viola extract group did not significantly differ in slee2022-01-01T00:00:00Z20222025-04-05T16:13:36.36Z2024-11-12T17:18:52.415ZS-EPMC92073803573447610.3389/fneur.2022.730311