{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Huang S"],"pubmed_abstract":["<b>Background:</b> Actin-related protein 2/3 complex subunit 2 (ARPC2) plays a fundamental role in actin filament nucleation and is critical for tumor cell migration and invasion. However, its abnormal expression, clinical significance, and biological function in human pan-cancer have been poorly explored. Thus, we focused on ARPC2 as an entry point for identifying novel pan-cancer prognostic biomarkers. <b>Methods:</b> The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases were used to assess the differential expression of ARPC2 in pan-cancer. The Human Protein Atlas was used for the tissue/cell-specific expression analysis of ARPC2. The genetic alteration information of ARPC2 was obtained from the cBioPortal database and the GSCALite platform. The prognostic v"],"journal":["Frontiers in cell and developmental biology"],"pagination":["896080"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9207441"],"repository":["biostudies-literature"],"pubmed_title":["ARPC2: A Pan-Cancer Prognostic and Immunological Biomarker That Promotes Hepatocellular Carcinoma Cell Proliferation and Invasion."],"pmcid":["PMC9207441"],"pubmed_authors":["Wu J","Huang S","Li D","Dong C","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"ARPC2: A Pan-Cancer Prognostic and Immunological Biomarker That Promotes Hepatocellular Carcinoma Cell Proliferation and Invasion.","description":"<b>Background:</b> Actin-related protein 2/3 complex subunit 2 (ARPC2) plays a fundamental role in actin filament nucleation and is critical for tumor cell migration and invasion. However, its abnormal expression, clinical significance, and biological function in human pan-cancer have been poorly explored. Thus, we focused on ARPC2 as an entry point for identifying novel pan-cancer prognostic biomarkers. <b>Methods:</b> The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases were used to assess the differential expression of ARPC2 in pan-cancer. The Human Protein Atlas was used for the tissue/cell-specific expression analysis of ARPC2. The genetic alteration information of ARPC2 was obtained from the cBioPortal database and the GSCALite platform. The prognostic v","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T13:28:59.546Z","creation":"2024-11-05T20:36:45.869Z"},"accession":"S-EPMC9207441","cross_references":{"pubmed":["35733852"],"doi":["10.3389/fcell.2022.896080"]}}