{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang X"],"funding":["Shanghai Science and Technology Committee","National Natural Science Foundation of China"],"pagination":["11281-11295"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9208480"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["As a novel noncoding RNA cluster, miR-17-92 cluster include six members: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a. Dysregulation of miR-17-92 has been proved to be connected with the advancement of a series of human diseases, but the roles of miR-17-92 cluster in non-small cell lung cancer (NSCLC) have not been absolutely elaborated. Herein, we determined that miR-17-92 cluster were upregulated significantly in NSCLC tissues, and the cell proliferation, migration and cycle progression of NSCLC were also facilitated under the function of miR-17-92 cluster. <i>Sprouty 4</i> (<i>SPRY4</i>) was a direct target of miR-92a, and its overexpression restrained the exacerbation of NSCLC induced by miR-92a. Furthermore, the tumor xenograft assay showed that miR-92a facilitated tumor "],"journal":["Bioengineered"],"pubmed_title":["Downregulated miR-18a and miR-92a synergistically suppress non-small cell lung cancer via targeting <i>Sprouty 4</i>."],"pmcid":["PMC9208480"],"funding_grant_id":["20S11901300","81572122"],"pubmed_authors":["Liu X","Zou H","Wu Z","Hua Z","Chai B","Zhang X","Ma Z","Wang W","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Downregulated miR-18a and miR-92a synergistically suppress non-small cell lung cancer via targeting <i>Sprouty 4</i>.","description":"As a novel noncoding RNA cluster, miR-17-92 cluster include six members: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a. Dysregulation of miR-17-92 has been proved to be connected with the advancement of a series of human diseases, but the roles of miR-17-92 cluster in non-small cell lung cancer (NSCLC) have not been absolutely elaborated. Herein, we determined that miR-17-92 cluster were upregulated significantly in NSCLC tissues, and the cell proliferation, migration and cycle progression of NSCLC were also facilitated under the function of miR-17-92 cluster. <i>Sprouty 4</i> (<i>SPRY4</i>) was a direct target of miR-92a, and its overexpression restrained the exacerbation of NSCLC induced by miR-92a. Furthermore, the tumor xenograft assay showed that miR-92a facilitated tumor ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-05T16:14:30.658Z","creation":"2025-04-05T16:14:30.658Z"},"accession":"S-EPMC9208480","cross_references":{"pubmed":["35484993"],"doi":["10.1080/21655979.2022.2066755"]}}