biostudies-literatureZhang XShanghai Science and Technology CommitteeNational Natural Science Foundation of China11281-11295https://www.ebi.ac.uk/biostudies/studies/S-EPMC9208480biostudies-literatureUnknown13(4)As a novel noncoding RNA cluster, miR-17-92 cluster include six members: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a. Dysregulation of miR-17-92 has been proved to be connected with the advancement of a series of human diseases, but the roles of miR-17-92 cluster in non-small cell lung cancer (NSCLC) have not been absolutely elaborated. Herein, we determined that miR-17-92 cluster were upregulated significantly in NSCLC tissues, and the cell proliferation, migration and cycle progression of NSCLC were also facilitated under the function of miR-17-92 cluster. <i>Sprouty 4</i> (<i>SPRY4</i>) was a direct target of miR-92a, and its overexpression restrained the exacerbation of NSCLC induced by miR-92a. Furthermore, the tumor xenograft assay showed that miR-92a facilitated tumor BioengineeredDownregulated miR-18a and miR-92a synergistically suppress non-small cell lung cancer via targeting <i>Sprouty 4</i>.PMC920848020S1190130081572122Liu XZou HWu ZHua ZChai BZhang XMa ZWang WWang XfalseDownregulated miR-18a and miR-92a synergistically suppress non-small cell lung cancer via targeting <i>Sprouty 4</i>.As a novel noncoding RNA cluster, miR-17-92 cluster include six members: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a. Dysregulation of miR-17-92 has been proved to be connected with the advancement of a series of human diseases, but the roles of miR-17-92 cluster in non-small cell lung cancer (NSCLC) have not been absolutely elaborated. Herein, we determined that miR-17-92 cluster were upregulated significantly in NSCLC tissues, and the cell proliferation, migration and cycle progression of NSCLC were also facilitated under the function of miR-17-92 cluster. <i>Sprouty 4</i> (<i>SPRY4</i>) was a direct target of miR-92a, and its overexpression restrained the exacerbation of NSCLC induced by miR-92a. Furthermore, the tumor xenograft assay showed that miR-92a facilitated tumor 2022-01-01T00:00:00Z2022 Apr2025-04-05T16:14:30.658Z2025-04-05T16:14:30.658ZS-EPMC92084803548499310.1080/21655979.2022.2066755