biostudies-literatureZhao SNational Key R&D Program of NingxiaNational Key R&D Program of NingxiaNational Natural Science Foundation of ChinaModern Agro-Industry Technology Research System of the PR ChinaFundamental Research Funds for Central Non-profit Scientific InstitutionGuangzhou Science and Technology Innovation Center370https://www.ebi.ac.uk/biostudies/studies/S-EPMC9209398biostudies-literatureUnknown79(7)Germ cell formation and embryonic development require ATP synthesized by mitochondria. The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are essential for the generation of energy. Mitofusin1 and mitofusin2, the homologues of Fuzzy onions in yeast and Drosophila, are critical regulators of mitochondrial fusion in mammalian cells. Since their discovery mitofusins (Mfns) have been the source of significant interest as key influencers of mitochondrial dynamics, including membrane fusion, mitochondrial distribution, and the interaction with other organelles. Emerging evidence has revealed significant insight into the role of Mfns in germ cell formation and embryonic development, as well as the high incidence of reproductive diseases such as asthenospermia, Cellular and molecular life sciences : CMLSMitofusins: from mitochondria to fertility.PMC92093982019-YWF-YB-03ASTIP-IAS072021BEF02023CARS-3632102549Zhao SHu ZZhang HZhu HHeng NWang HGong JfalseMitofusins: from mitochondria to fertility.Germ cell formation and embryonic development require ATP synthesized by mitochondria. The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are essential for the generation of energy. Mitofusin1 and mitofusin2, the homologues of Fuzzy onions in yeast and Drosophila, are critical regulators of mitochondrial fusion in mammalian cells. Since their discovery mitofusins (Mfns) have been the source of significant interest as key influencers of mitochondrial dynamics, including membrane fusion, mitochondrial distribution, and the interaction with other organelles. Emerging evidence has revealed significant insight into the role of Mfns in germ cell formation and embryonic development, as well as the high incidence of reproductive diseases such as asthenospermia, 2022-01-01T00:00:00Z2022 Jun2025-04-18T19:39:14.328Z2024-11-11T21:20:34.527ZS-EPMC92093983572594810.1007/s00018-022-04386-z