{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Li Y"],"pubmed_abstract":["The N6-methyladenosine (m<sup>6</sup>A) modification acts as a dynamic regulatory factor in diseases by regulating the metabolism and function of the transcriptome, especially mRNAs. However, little is known regarding the functional effects of m<sup>6</sup>A modifications on circRNAs. In this research, we established a distal middle cerebral artery occlusion (MCAO) model in adult C57BL/6J mice. The mice were divided into three groups: sham surgery, 3 days after MCAO (3d), and 7 days after MCAO (7d). Reverse transcription quantitative polymerase chain reaction (RT-qPCR) demonstrated that the mRNA expression levels of m<sup>6</sup>A-related methyltransferases (METTL3, METTL14), demethylases (FTO, ALKBH5), and reading proteins (YTHDF1, YTHDF3) altered compared to the sham group. Furthermore, "],"journal":["Frontiers in neuroscience"],"pagination":["869081"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9209773"],"repository":["biostudies-literature"],"pubmed_title":["The Alteration Profiles of m<sup>6</sup>A-Tagged circRNAs in the Peri-Infarct Cortex After Cerebral Ischemia in Mice."],"pmcid":["PMC9209773"],"pubmed_authors":["Zhang W","Li H","Li X","Li Y","Chen Z","Li F","Ling L","Luo Y"],"additional_accession":[]},"is_claimable":false,"name":"The Alteration Profiles of m<sup>6</sup>A-Tagged circRNAs in the Peri-Infarct Cortex After Cerebral Ischemia in Mice.","description":"The N6-methyladenosine (m<sup>6</sup>A) modification acts as a dynamic regulatory factor in diseases by regulating the metabolism and function of the transcriptome, especially mRNAs. However, little is known regarding the functional effects of m<sup>6</sup>A modifications on circRNAs. In this research, we established a distal middle cerebral artery occlusion (MCAO) model in adult C57BL/6J mice. The mice were divided into three groups: sham surgery, 3 days after MCAO (3d), and 7 days after MCAO (7d). Reverse transcription quantitative polymerase chain reaction (RT-qPCR) demonstrated that the mRNA expression levels of m<sup>6</sup>A-related methyltransferases (METTL3, METTL14), demethylases (FTO, ALKBH5), and reading proteins (YTHDF1, YTHDF3) altered compared to the sham group. Furthermore, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T19:39:18.992Z","creation":"2024-11-11T21:21:55.342Z"},"accession":"S-EPMC9209773","cross_references":{"pubmed":["35747214"],"doi":["10.3389/fnins.2022.869081"]}}