{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Lanuza PM"],"pubmed_abstract":["<h4>Background</h4>Colorectal cancer (CRC) is a heterogeneous disease with variable mutational profile and tumour microenvironment composition that influence tumour progression and response to treatment. While chemoresistant and poorly immunogenic CRC remains a challenge, the development of new strategies guided by biomarkers could help stratify and treat patients. Allogeneic NK cell transfer emerges as an alternative against chemoresistant and poorly immunogenic CRC.<h4>Methods</h4>NK cell-related immunological markers were analysed by transcriptomics and immunohistochemistry in human CRC samples and correlated with tumour progression and overall survival. The anti-tumour ability of expanded allogeneic NK cells using a protocol combining cytokines and feeder cells was analysed <i>in vitro"],"journal":["Frontiers in immunology"],"pagination":["890836"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9210952"],"repository":["biostudies-literature"],"pubmed_title":["Adoptive NK Cell Transfer as a Treatment in Colorectal Cancer Patients: Analyses of Tumour Cell Determinants Correlating With Efficacy <i>In Vitro</i> and <i>In Vivo</i>."],"pmcid":["PMC9210952"],"pubmed_authors":["Lanuza PM","Redrado S","Pesini C","Sanz-Pamplona R","Jaime-Sanchez P","Arias M","Santiago L","Comas L","Pazo-Cid R","Garcia-Mulero S","Uranga-Murillo I","Santos C","Ramirez-Labrada A","Pardo J","Alonso MH","Arnau R","Agustin-Ferrandez MJ","Hidalgo S","Sanjuan X","Galvez EM"],"additional_accession":[]},"is_claimable":false,"name":"Adoptive NK Cell Transfer as a Treatment in Colorectal Cancer Patients: Analyses of Tumour Cell Determinants Correlating With Efficacy <i>In Vitro</i> and <i>In Vivo</i>.","description":"<h4>Background</h4>Colorectal cancer (CRC) is a heterogeneous disease with variable mutational profile and tumour microenvironment composition that influence tumour progression and response to treatment. While chemoresistant and poorly immunogenic CRC remains a challenge, the development of new strategies guided by biomarkers could help stratify and treat patients. Allogeneic NK cell transfer emerges as an alternative against chemoresistant and poorly immunogenic CRC.<h4>Methods</h4>NK cell-related immunological markers were analysed by transcriptomics and immunohistochemistry in human CRC samples and correlated with tumour progression and overall survival. The anti-tumour ability of expanded allogeneic NK cells using a protocol combining cytokines and feeder cells was analysed <i>in vitro","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-09T14:26:30.209Z","creation":"2024-12-03T23:28:49.885Z"},"accession":"S-EPMC9210952","cross_references":{"pubmed":["35747143"],"doi":["10.3389/fimmu.2022.890836"]}}