biostudies-literatureUnknown13Lanuza PM<h4>Background</h4>Colorectal cancer (CRC) is a heterogeneous disease with variable mutational profile and tumour microenvironment composition that influence tumour progression and response to treatment. While chemoresistant and poorly immunogenic CRC remains a challenge, the development of new strategies guided by biomarkers could help stratify and treat patients. Allogeneic NK cell transfer emerges as an alternative against chemoresistant and poorly immunogenic CRC.<h4>Methods</h4>NK cell-related immunological markers were analysed by transcriptomics and immunohistochemistry in human CRC samples and correlated with tumour progression and overall survival. The anti-tumour ability of expanded allogeneic NK cells using a protocol combining cytokines and feeder cells was analysed <i>in vitroFrontiers in immunology890836https://www.ebi.ac.uk/biostudies/studies/S-EPMC9210952biostudies-literatureAdoptive NK Cell Transfer as a Treatment in Colorectal Cancer Patients: Analyses of Tumour Cell Determinants Correlating With Efficacy <i>In Vitro</i> and <i>In Vivo</i>.PMC9210952Lanuza PMRedrado SPesini CSanz-Pamplona RJaime-Sanchez PArias MSantiago LComas LPazo-Cid RGarcia-Mulero SUranga-Murillo ISantos CRamirez-Labrada APardo JAlonso MHArnau RAgustin-Ferrandez MJHidalgo SSanjuan XGalvez EMfalseAdoptive NK Cell Transfer as a Treatment in Colorectal Cancer Patients: Analyses of Tumour Cell Determinants Correlating With Efficacy <i>In Vitro</i> and <i>In Vivo</i>.<h4>Background</h4>Colorectal cancer (CRC) is a heterogeneous disease with variable mutational profile and tumour microenvironment composition that influence tumour progression and response to treatment. While chemoresistant and poorly immunogenic CRC remains a challenge, the development of new strategies guided by biomarkers could help stratify and treat patients. Allogeneic NK cell transfer emerges as an alternative against chemoresistant and poorly immunogenic CRC.<h4>Methods</h4>NK cell-related immunological markers were analysed by transcriptomics and immunohistochemistry in human CRC samples and correlated with tumour progression and overall survival. The anti-tumour ability of expanded allogeneic NK cells using a protocol combining cytokines and feeder cells was analysed <i>in vitro2022-01-01T00:00:00Z20222026-05-09T14:26:30.209Z2024-12-03T23:28:49.885ZS-EPMC92109523574714310.3389/fimmu.2022.890836