biostudies-literatureUnknownLaskow TJohns Hopkins Older Americans Independence CenterNIA NIH HHSSalisbury Family FoundationNational Institute on Aging<h4>Background</h4>Chronic inflammation (CI) is a common trait of aging associated with adverse outcomes including mortality. We hypothesized that recombinant human Lactoferrin (rhLf) would reduce chronic inflammation of aging.<h4>Methods</h4>Thirty-six community dwelling older adults were randomly assigned to rhLf or placebo treatment in 1:1 ratio for 3 months. IL-6, sTNFR1, Comprehensive Metabolic Panel (CMP), and Complete Blood Count (CBC) were measured at baseline, 1 month, 3 months, and 6 months. Physical and cognitive measures were completed at same timepoints, including 4-m walking speed (m/s), grip strength (kg), 6-min walking distance (m), home activity measured by accelerometer, trail making test - Part A (s) and - Part B (s), and Digit symbol substitution test (number correctly Physiology internationalhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9211386biostudies-literatureLactoferrin for the treatment of age-associated inflammation - A pilot study.PMC9211386P30 AG021334R21 AG053681P30 AG024827T32 AG058527Laskow TWalston JLangdon JAbadir PXue QLfalseLactoferrin for the treatment of age-associated inflammation - A pilot study.<h4>Background</h4>Chronic inflammation (CI) is a common trait of aging associated with adverse outcomes including mortality. We hypothesized that recombinant human Lactoferrin (rhLf) would reduce chronic inflammation of aging.<h4>Methods</h4>Thirty-six community dwelling older adults were randomly assigned to rhLf or placebo treatment in 1:1 ratio for 3 months. IL-6, sTNFR1, Comprehensive Metabolic Panel (CMP), and Complete Blood Count (CBC) were measured at baseline, 1 month, 3 months, and 6 months. Physical and cognitive measures were completed at same timepoints, including 4-m walking speed (m/s), grip strength (kg), 6-min walking distance (m), home activity measured by accelerometer, trail making test - Part A (s) and - Part B (s), and Digit symbol substitution test (number correctly 2021-01-01T00:00:00Z2021 Apr2026-05-09T10:49:45.103Z2024-11-21T04:25:08.542ZS-EPMC92113863384464210.1556/2060.2021.00010