{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Damme KSF"],"funding":["Swiss National Science Foundation","NIDA NIH HHS","National Institutes of Mental Health","NIMH NIH HHS","National Institutes of Health","NIH HHS","SW Grant Swiss National Science Foundation"],"pagination":["752-762"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9212095"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(4)"],"pubmed_abstract":["<h4>Background</h4>Motor abnormalities are strong transdiagnostic indicators of psychopathology risk that reflect emerging neural network abnormalities. Indeed, motor signs, such as motor slowing and agitation, are widely recognized as core features of both psychosis and depression. However, it is unclear whether these reflect shared or distinct etiology.<h4>Methods</h4>A sample of 11 878 adolescents completed self-reported clinical measures of rated psychotic-like experiences (PLEs) and depression. Familial risk for psychopathology and the presence of motor signs were drawn from parental reports, including developmental motor delays (eg, sitting, walking), and adolescent motor signs (eg, dyscoordination, psychomotor retardation, and psychomotor agitation). Finally, motor network connectiv"],"journal":["Schizophrenia bulletin"],"pubmed_title":["Depression and Psychosis Risk Shared Vulnerability for Motor Signs Across Development, Symptom Dimensions, and Familial Risk."],"pmcid":["PMC9212095"],"funding_grant_id":["R01MH119771","U24 DA041123","U01 DA041117","U24 DA041147","R01MH118741","R21/R33MH103231","R01MH112545","T32MH126368","U01DA041106","U01 DA041174","U01DA041028","R01MH112545–01","U01DA041148","U01DA041048","U01DA041025","U01 DA041134","U01 DA041156","U01DA041089","U01DA041022","U01DA041120","184717","R33 MH103231","U01 DA041093","R21 MH103231","182469","U01 DA041106","R01 MH094650","R01 MH119771","R01MH094650","U01 DA041028","R01 MH112545","R01 MH118741","U01 DA041089","U01 DA041022","U01 DA041120","U01DA041117","U24DA041147","U01 DA041148","U01 DA041048","U01 DA041025","U24DA041123","U01DA041134","U01DA041156","T32 MH126368","U01DA041174","R01MH103231","U01DA041093"],"pubmed_authors":["Shankman SA","Damme KSF","Vargas T","Walther S","Mittal VA","Park JS"],"additional_accession":[]},"is_claimable":false,"name":"Depression and Psychosis Risk Shared Vulnerability for Motor Signs Across Development, Symptom Dimensions, and Familial Risk.","description":"<h4>Background</h4>Motor abnormalities are strong transdiagnostic indicators of psychopathology risk that reflect emerging neural network abnormalities. Indeed, motor signs, such as motor slowing and agitation, are widely recognized as core features of both psychosis and depression. However, it is unclear whether these reflect shared or distinct etiology.<h4>Methods</h4>A sample of 11 878 adolescents completed self-reported clinical measures of rated psychotic-like experiences (PLEs) and depression. Familial risk for psychopathology and the presence of motor signs were drawn from parental reports, including developmental motor delays (eg, sitting, walking), and adolescent motor signs (eg, dyscoordination, psychomotor retardation, and psychomotor agitation). Finally, motor network connectiv","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-05-28T00:33:01.935Z","creation":"2025-04-06T01:51:11.874Z"},"accession":"S-EPMC9212095","cross_references":{"pubmed":["35554607"],"doi":["10.1093/schbul/sbab133"]}}