{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Longenecker JM"],"funding":["National Institutes of Mental Health","NIMH NIH HHS"],"pagination":["893-901"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9212103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(4)"],"pubmed_abstract":["<h4>Background and hypothesis</h4>Quantitative models of psychopathology can empirically guide subclassification of heterogeneous clinical presentations such as psychosis; they are particularly well-equipped to capture the nuanced symptomatology observed in first-episode psychosis. As well, components may be better aligned with biological variables. The current study sought to confirm and extend knowledge of the hierarchical structure of psychosis symptoms in first-episode psychosis. Based on past hierarchical work, we hypothesized that a 4 component level would be most closely associated with longitudinal disability.<h4>Study design</h4>Participants with early-stage psychosis (N = 370) underwent clinical assessment with the scale for the assessment of positive symptoms (SAPS), scale for a"],"journal":["Schizophrenia bulletin"],"pubmed_title":["Hierarchical Symptom Components in Early Psychosis."],"pmcid":["PMC9212103"],"funding_grant_id":["R01 MH113533","R01 MH108568"],"pubmed_authors":["Longenecker JM","Haas GL","Salisbury DF"],"additional_accession":[]},"is_claimable":false,"name":"Hierarchical Symptom Components in Early Psychosis.","description":"<h4>Background and hypothesis</h4>Quantitative models of psychopathology can empirically guide subclassification of heterogeneous clinical presentations such as psychosis; they are particularly well-equipped to capture the nuanced symptomatology observed in first-episode psychosis. As well, components may be better aligned with biological variables. The current study sought to confirm and extend knowledge of the hierarchical structure of psychosis symptoms in first-episode psychosis. Based on past hierarchical work, we hypothesized that a 4 component level would be most closely associated with longitudinal disability.<h4>Study design</h4>Participants with early-stage psychosis (N = 370) underwent clinical assessment with the scale for the assessment of positive symptoms (SAPS), scale for a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-19T02:40:11.988Z","creation":"2025-04-19T02:40:11.988Z"},"accession":"S-EPMC9212103","cross_references":{"pubmed":["35639737"],"doi":["10.1093/schbul/sbac048"]}}