biostudies-literatureLongenecker JMNational Institutes of Mental HealthNIMH NIH HHS893-901https://www.ebi.ac.uk/biostudies/studies/S-EPMC9212103biostudies-literatureUnknown48(4)<h4>Background and hypothesis</h4>Quantitative models of psychopathology can empirically guide subclassification of heterogeneous clinical presentations such as psychosis; they are particularly well-equipped to capture the nuanced symptomatology observed in first-episode psychosis. As well, components may be better aligned with biological variables. The current study sought to confirm and extend knowledge of the hierarchical structure of psychosis symptoms in first-episode psychosis. Based on past hierarchical work, we hypothesized that a 4 component level would be most closely associated with longitudinal disability.<h4>Study design</h4>Participants with early-stage psychosis (N = 370) underwent clinical assessment with the scale for the assessment of positive symptoms (SAPS), scale for aSchizophrenia bulletinHierarchical Symptom Components in Early Psychosis.PMC9212103R01 MH113533R01 MH108568Longenecker JMHaas GLSalisbury DFfalseHierarchical Symptom Components in Early Psychosis.<h4>Background and hypothesis</h4>Quantitative models of psychopathology can empirically guide subclassification of heterogeneous clinical presentations such as psychosis; they are particularly well-equipped to capture the nuanced symptomatology observed in first-episode psychosis. As well, components may be better aligned with biological variables. The current study sought to confirm and extend knowledge of the hierarchical structure of psychosis symptoms in first-episode psychosis. Based on past hierarchical work, we hypothesized that a 4 component level would be most closely associated with longitudinal disability.<h4>Study design</h4>Participants with early-stage psychosis (N = 370) underwent clinical assessment with the scale for the assessment of positive symptoms (SAPS), scale for a2022-01-01T00:00:00Z2022 Jun2025-04-19T02:40:11.988Z2025-04-19T02:40:11.988ZS-EPMC92121033563973710.1093/schbul/sbac048