{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Villas-Boas L"],"pubmed_abstract":["<h4>Objectives</h4> The aim of the present study was to evaluate if neutralizing antibody responses induced by infection with the SARS-CoV-2 strain that was dominant at the beginning of the pandemic or by the Gamma variant was effective against the Omicron variant. <h4>Methods</h4> Convalescent sera from 109 individuals, never exposed to a SARS-CoV-2 vaccine, who had mild or moderate symptoms not requiring hospitalization following either a documented SARS-CoV-2 ancestral strain infection or a Gamma variant infection, were assayed for in vitro neutralizing antibody activity against their original strains and the Omicron variant. <h4>Results</h4> Following an infection with the ancestral strain, 56 (93.3%), 45 (77.6%) and 1 (1.7%) serum sample were positive for neutralizing antibodies again"],"journal":["Clinics (Sao Paulo, Brazil)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9212906"],"repository":["biostudies-literature"],"pubmed_title":["Absence of neutralizing antibodies against the Omicron SARS-CoV-2 variant in convalescent sera from individuals infected with the ancestral SARS-CoV-2 virus or its Gamma variant"],"pmcid":["PMC9212906"],"pubmed_authors":["Paula A","Manuli E","Paiao H","Leal F","Mendes-Correa M","Tozetto-Mendoza T","Silva A","Witkin S","Villas-Boas L","Ferraz A","Bierrenbach A","Sabino E"],"additional_accession":[]},"is_claimable":false,"name":"Absence of neutralizing antibodies against the Omicron SARS-CoV-2 variant in convalescent sera from individuals infected with the ancestral SARS-CoV-2 virus or its Gamma variant","description":"<h4>Objectives</h4> The aim of the present study was to evaluate if neutralizing antibody responses induced by infection with the SARS-CoV-2 strain that was dominant at the beginning of the pandemic or by the Gamma variant was effective against the Omicron variant. <h4>Methods</h4> Convalescent sera from 109 individuals, never exposed to a SARS-CoV-2 vaccine, who had mild or moderate symptoms not requiring hospitalization following either a documented SARS-CoV-2 ancestral strain infection or a Gamma variant infection, were assayed for in vitro neutralizing antibody activity against their original strains and the Omicron variant. <h4>Results</h4> Following an infection with the ancestral strain, 56 (93.3%), 45 (77.6%) and 1 (1.7%) serum sample were positive for neutralizing antibodies again","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-19T19:20:30.485Z","creation":"2025-04-19T19:20:30.485Z"},"accession":"S-EPMC9212906","cross_references":{}}