{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ahmed K"],"funding":["Higher Education Commision, Pakistan,Pakistan"],"pagination":["10399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9213544"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["The pathophysiology of prostate cancer involves both genetic and acquired factors, including pathogens, such as viruses. A limited number of studies have shown the presence of Epstein-Barr virus (EBV) in prostate cancer tissues. However, there is a dearth of data exploring EBV latency profile in prostate cancer, and the relationship of EBV with histopathological features of prostate cancer. In this study, prostate cancer and benign prostatic hyperplasia (BPH) samples were screened for the presence of EBV, followed by the characterization of the EBV latency profile and analysis of histopathological parameters in EBV-positive and EBV-negative groups. A conventional PCR strategy was employed using virus-specific primers to screen EBV in 99 formalin-fixed paraffin-embedded (FFPE) prostate canc"],"journal":["Scientific reports"],"pubmed_title":["Detection and characterization of latency stage of EBV and histopathological analysis of prostatic adenocarcinoma tissues."],"pmcid":["PMC9213544"],"funding_grant_id":["8722/Sindh/ NRPU/R&D/HEC/ 2017"],"pubmed_authors":["Ghias K","Abidi SH","Haider G","Sheikh A","Abbas F","Ahmed K","Fatima S","Mughal N"],"additional_accession":[]},"is_claimable":false,"name":"Detection and characterization of latency stage of EBV and histopathological analysis of prostatic adenocarcinoma tissues.","description":"The pathophysiology of prostate cancer involves both genetic and acquired factors, including pathogens, such as viruses. A limited number of studies have shown the presence of Epstein-Barr virus (EBV) in prostate cancer tissues. However, there is a dearth of data exploring EBV latency profile in prostate cancer, and the relationship of EBV with histopathological features of prostate cancer. In this study, prostate cancer and benign prostatic hyperplasia (BPH) samples were screened for the presence of EBV, followed by the characterization of the EBV latency profile and analysis of histopathological parameters in EBV-positive and EBV-negative groups. A conventional PCR strategy was employed using virus-specific primers to screen EBV in 99 formalin-fixed paraffin-embedded (FFPE) prostate canc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-21T23:05:17.817Z","creation":"2025-04-05T18:58:30.954Z"},"accession":"S-EPMC9213544","cross_references":{"pubmed":["35729214"],"doi":["10.1038/s41598-022-14511-4"]}}