biostudies-literatureWoodruff RCIntramural CDC HHSCDC HHSe2021053418https://www.ebi.ac.uk/biostudies/studies/S-EPMC9213563biostudies-literatureUnknown149(1)<h4>Objectives</h4>Describe population-based rates and risk factors for severe coronavirus disease 2019 (COVID-19) (ie, ICU admission, invasive mechanical ventilation, or death) among hospitalized children.<h4>Methods</h4>During March 2020 to May 2021, the COVID-19-Associated Hospitalization Surveillance Network identified 3106 children hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection in 14 states. Among 2293 children primarily admitted for COVID-19, multivariable generalized estimating equations generated adjusted risk ratios (aRRs) and 95% confidence intervals (CIs) of the associations between demographic and medical characteristics abstracted from medical records and severe COVID-19. We calculated age-adjusted cumulative population-based rPediatricsRisk Factors for Severe COVID-19 in Children.PMC9213563CC999999NU38OT000297Sosin DMPham HTalbot HKBye EChai SJWhitaker MMeek JBilling LMWoodruff RCReeg LSutton MP Havers FKawasaki BTaylor CAMuse ABennett NMAnderson EJL McMorrow MMcCaffrey KWeigel AMonroe MLCampbell APPatel KfalseRisk Factors for Severe COVID-19 in Children.<h4>Objectives</h4>Describe population-based rates and risk factors for severe coronavirus disease 2019 (COVID-19) (ie, ICU admission, invasive mechanical ventilation, or death) among hospitalized children.<h4>Methods</h4>During March 2020 to May 2021, the COVID-19-Associated Hospitalization Surveillance Network identified 3106 children hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection in 14 states. Among 2293 children primarily admitted for COVID-19, multivariable generalized estimating equations generated adjusted risk ratios (aRRs) and 95% confidence intervals (CIs) of the associations between demographic and medical characteristics abstracted from medical records and severe COVID-19. We calculated age-adjusted cumulative population-based r2022-01-01T00:00:00Z2022 Jan2025-04-19T18:09:15.918Z2025-04-19T18:09:15.918ZS-EPMC92135633493503810.1542/peds.2021-053418