{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Neumann JT"],"funding":["Monash University","NIA NIH HHS"],"pagination":["1641-1655"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9213595"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(3)"],"pubmed_abstract":["Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in"],"journal":["GeroScience"],"pubmed_title":["Prediction of disability-free survival in healthy older people."],"pmcid":["PMC9213595"],"funding_grant_id":["U01 AG029824","U19 AG062682"],"pubmed_authors":["Toohill G","Dawe N","Lane R","Flanagan T","Parghi N","Mah S","Alwyn T","Sleaby E","Davies-Hakeem A","Hines C","Flanagan D","Nicola N","Renshaw P","Crowe P","Afroze S","Spring M","Lapin S","Roebuck R","Busch G","Dang D","Russell G","Keillar P","Arakji AM","Africa N","Wong PT","Liedvogel M","Andre S","Kitchen J","Shute J","Hutchinson A","Rounsevell J","Alagarswami K","White G","Choo E","Fryer D","Tunaley S","White R","Roche V","Yu Z","White A","Conron D","Mbachilin G","Kuay V","Hookham D","Teo K","Rapley M","Ramsey J","Manson J","Elshenawy I","Aung K","Lockery J","Goy P","Zimmerman J","Haddad J","Sherley M","Murray S","Thiru K","Thiru M","Sandrasegaram S","Dunn S","Haddad M","Brophy T","Murray A","Ferruccio A","Murray B","Paransothy P","Sharma 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T","Nikolovska-Buzevski N","Wild I","Manton D"],"additional_accession":[]},"is_claimable":false,"name":"Prediction of disability-free survival in healthy older people.","description":"Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-07-14T21:52:31.821Z","creation":"2025-02-19T02:43:51.882Z"},"accession":"S-EPMC9213595","cross_references":{"pubmed":["35420334"],"doi":["10.1007/s11357-022-00547-x"]}}