biostudies-literatureNeumann JTMonash UniversityNIA NIH HHS1641-1655https://www.ebi.ac.uk/biostudies/studies/S-EPMC9213595biostudies-literatureUnknown44(3)Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. 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MMedlicott MThorpe VDuane PHo LMendis LRothfield JMacrae FRoufael ADHedgland AJamel BMenzies JHyam Pvan Londen GLukic NGurney RCameron DLong MSteer NCameron AHolder BHogbin JBettiol LRogers SNewman ADadabhay ZHermiz SHowson WReza RRogers DWilliamson JBlashki MSchneeweiss AShmerling ABanerjee PFlew SJoshi MNikolic VJoshi NSharif ACruickshank JMcLaren GCampbell RHarmer DButrev ADe Silva MDe Silva PHamel JMichaelson TCampbell DCampbell GMagill MBatchelor LVolpi ECameron TNikolovska-Buzevski NWild IManton DfalsePrediction of disability-free survival in healthy older people.Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in2022-01-01T00:00:00Z2022 Jun2026-07-14T21:52:31.821Z2025-02-19T02:43:51.882ZS-EPMC92135953542033410.1007/s11357-022-00547-x