{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["44(3)"],"submitter":["Ozzoude M"],"funding":["Baycrest Foundation","the Windsor/Essex County ALS Association","Centre for Addiction and Mental Health Foundation","Ottawa Brain and Mind Research Institute","Queen’s University Faculty of Health Sciences","London Health Sciences Foundation","the University of Ottawa Faculty of Medicine","Bruyere Research Institute","the Thunder Bay Regional Health Sciences Centre","McMaster University Faculty of Health Sciences","Ontario Brain Institute","The Temerty Family Foundation","University Health Network"],"pubmed_abstract":["Change in empathy is an increasingly recognised symptom of neurodegenerative diseases and contributes to caregiver burden and patient distress. Empathy impairment has been associated with brain atrophy but its relationship to white matter hyperintensities (WMH) is unknown. We aimed to investigate the relationships amongst WMH, brain atrophy, and empathy deficits in neurodegenerative and cerebrovascular diseases. Five hundred thirteen participants with Alzheimer's disease/mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), Parkinson's disease, or cerebrovascular disease (CVD) were included. Empathy was assessed using the Interpersonal Reactivity Index. WMH were measured using a semi-automatic segmentation and FreeSurfer was used to measure cortical thick"],"journal":["GeroScience"],"pagination":["1575-1598"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9213606"],"repository":["biostudies-literature"],"pubmed_title":["Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases."],"pmcid":["PMC9213606"],"pubmed_authors":["Hudson C","Mandelcorn E","Strong M","Jog M","Hegele R","Sujanthan S","Shoesmith C","Fischer CE","Frank A","Grimes D","Woulfe J","Zinman L","Seitz D","Sahlas D","Levine B","Ramirez J","Breen DP","ONDRI Investigators","Rogaeva E","Bartha R","Kwan D","Turnbull J","Dixon RA","McIlroy B","Peltsch A","McLaughlin P","Marras C","Tartaglia MC","Troyer A","Swartz RH","Saposnik G","Pollock BG","Symons S","Faria F","Lawrence-Dewar J","Nanayakkara N","Rabin J","Orange JB","Strother SC","Zamyadi M","Lang AE","Black SE","Black A","Casaubon L","Adamo S","Sarquis-Adamson Y","Ghani M","Roberts A","Sunderland KM","Tang-Wai DF","Steeves TDL","Kleinstiver P","Abrahao A","Hatch W","Lou W","Gao F","Kumar S","Chum M","Goubran M","Hassan A","Fraser J","Greenberg B","Scott CJM","Rajji TK","Chen Y","Cornish B","Freedman M","Holmes MF","Zou GG","Masellis M","Tan B","Tayyari F","Bronskil S","Theyers A","Defrawy S","Dowlatshahi D","Ozzoude M","Farhan S","Van Ooteghem K","Binns M","Uthirakumaran A","Berezuk C","Borrie M","Rashkovan N","Varriano B","Haddad SMH","Brien D","Munoz D","Coe B","Robinson J","Beaton D","Pasternak S","Margolin E","Mandzia J","Arnott SR","Dilliott AA","Leontieva E","Bulman D","Montero-Odasso M","Southwell A","Finger E"],"additional_accession":[]},"is_claimable":false,"name":"Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases.","description":"Change in empathy is an increasingly recognised symptom of neurodegenerative diseases and contributes to caregiver burden and patient distress. Empathy impairment has been associated with brain atrophy but its relationship to white matter hyperintensities (WMH) is unknown. We aimed to investigate the relationships amongst WMH, brain atrophy, and empathy deficits in neurodegenerative and cerebrovascular diseases. Five hundred thirteen participants with Alzheimer's disease/mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), Parkinson's disease, or cerebrovascular disease (CVD) were included. Empathy was assessed using the Interpersonal Reactivity Index. WMH were measured using a semi-automatic segmentation and FreeSurfer was used to measure cortical thick","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-19T05:55:23.725Z","creation":"2024-11-12T11:00:00.61Z"},"accession":"S-EPMC9213606","cross_references":{"pubmed":["35294697"],"doi":["10.1007/s11357-022-00539-x"]}}