biostudies-literatureUnknown17(1)Parisi FThe mouse mammary tumour virus (MMTV) is implicated in the aetiology of murine mammary carcinomas and a variant of it, the type B leukemogenic virus, can cause murine thymic lymphomas. Interestingly, a MMTV-like virus is suspected to be involved in human breast cancer and feline mammary carcinomas. However, to date, no cases of MMTV-like sequence amplifications have been described in lymphoid neoplasms in veterinary literature. The aim of this study was to investigate the presence of env nucleotide sequences and protein 14 (p14) of a MMTV-like virus in fifty-three feline lymphoma samples. Our results show that MMTV-like sequences were detected in 5/53 tumours (9.4%): three gastrointestinal lymphomas (one B-type diffuse large, one B-type small non-cleaved, and one T-type diffuse mixed lymphInfectious agents and cancer35https://www.ebi.ac.uk/biostudies/studies/S-EPMC9219121biostudies-literaturePresence of a mouse mammary tumour virus-like in feline lymphomas: a preliminary study.PMC9219121Civita PMenicagli MLiotti RParisi FFreer GMazzanti CMLessi FPistello MMillanta FPoli AfalsePresence of a mouse mammary tumour virus-like in feline lymphomas: a preliminary study.The mouse mammary tumour virus (MMTV) is implicated in the aetiology of murine mammary carcinomas and a variant of it, the type B leukemogenic virus, can cause murine thymic lymphomas. Interestingly, a MMTV-like virus is suspected to be involved in human breast cancer and feline mammary carcinomas. However, to date, no cases of MMTV-like sequence amplifications have been described in lymphoid neoplasms in veterinary literature. The aim of this study was to investigate the presence of env nucleotide sequences and protein 14 (p14) of a MMTV-like virus in fifty-three feline lymphoma samples. Our results show that MMTV-like sequences were detected in 5/53 tumours (9.4%): three gastrointestinal lymphomas (one B-type diffuse large, one B-type small non-cleaved, and one T-type diffuse mixed lymph2022-01-01T00:00:00Z2022 Jun2025-04-18T19:40:44.993Z2024-11-11T21:22:45.931ZS-EPMC92191213573960210.1186/s13027-022-00449-9