{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ho CC"],"funding":["National Health Research Institutes, Taiwan","Ministry of Science and Technology, Taiwan"],"pagination":["43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9219152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["

Background

Exposure to ambient fine particulate matter (PM2.5) is associated with vascular diseases. Polycyclic aromatic hydrocarbons (PAHs) in PM2.5 are highly hazardous; however, the contribution of PM2.5-bound PAHs to PM2.5-associated vascular diseases remains unclear. The ToxCast high-throughput in vitro screening database indicates that some PM2.5-bound PAHs activate the aryl hydrocarbon receptor (AhR). The present study investigated whether the AhR pathway is involved in the mechanism of PM2.5-induced vascular toxicity, identified the PAH in PM2.5 that was the major contributor of AhR activation, and identified a biomarker for vascular toxicity of PM2.5-bound PAHs.

Results

Treatment"],"journal":["Particle and fibre toxicology"],"pubmed_title":["Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker."],"pmcid":["PMC9219152"],"funding_grant_id":["MOST 110-2320-B-400-008","NHRI-110EMPP02"],"pubmed_authors":["Ho CC","Wu WT","Lin P","Chen YC","Yet SF","Lin YJ","Weng CY","Tsai HT","Tsai MH"],"additional_accession":[]},"is_claimable":false,"name":"Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker.","description":"

Background

Exposure to ambient fine particulate matter (PM2.5) is associated with vascular diseases. Polycyclic aromatic hydrocarbons (PAHs) in PM2.5 are highly hazardous; however, the contribution of PM2.5-bound PAHs to PM2.5-associated vascular diseases remains unclear. The ToxCast high-throughput in vitro screening database indicates that some PM2.5-bound PAHs activate the aryl hydrocarbon receptor (AhR). The present study investigated whether the AhR pathway is involved in the mechanism of PM2.5-induced vascular toxicity, identified the PAH in PM2.5 that was the major contributor of AhR activation, and identified a biomarker for vascular toxicity of PM2.5-bound PAHs.

Results

Treatment","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-06-03T10:19:06.403Z","creation":"2025-02-19T03:22:28.064Z"},"accession":"S-EPMC9219152","cross_references":{"pubmed":["35739584"],"doi":["10.1186/s12989-022-00482-x"]}}