biostudies-literatureHo CCNational Health Research Institutes, TaiwanMinistry of Science and Technology, Taiwan43https://www.ebi.ac.uk/biostudies/studies/S-EPMC9219152biostudies-literatureUnknown19(1)<h4>Background</h4>Exposure to ambient fine particulate matter (PM_2.5) is associated with vascular diseases. Polycyclic aromatic hydrocarbons (PAHs) in PM_2.5 are highly hazardous; however, the contribution of PM_2.5-bound PAHs to PM_2.5-associated vascular diseases remains unclear. The ToxCast high-throughput in vitro screening database indicates that some PM_2.5-bound PAHs activate the aryl hydrocarbon receptor (AhR). The present study investigated whether the AhR pathway is involved in the mechanism of PM_2.5-induced vascular toxicity, identified the PAH in PM_2.5 that was the major contributor of AhR activation, and identified a biomarker for vascular toxicity of PM_2.5-bound PAHs.<h4>Results</h4>TreatmentParticle and fibre toxicologyAryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker.PMC9219152MOST 110-2320-B-400-008NHRI-110EMPP02Ho CCWu WTLin PChen YCYet SFLin YJWeng CYTsai HTTsai MHfalseAryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker.<h4>Background</h4>Exposure to ambient fine particulate matter (PM_2.5) is associated with vascular diseases. Polycyclic aromatic hydrocarbons (PAHs) in PM_2.5 are highly hazardous; however, the contribution of PM_2.5-bound PAHs to PM_2.5-associated vascular diseases remains unclear. The ToxCast high-throughput in vitro screening database indicates that some PM_2.5-bound PAHs activate the aryl hydrocarbon receptor (AhR). The present study investigated whether the AhR pathway is involved in the mechanism of PM_2.5-induced vascular toxicity, identified the PAH in PM_2.5 that was the major contributor of AhR activation, and identified a biomarker for vascular toxicity of PM_2.5-bound PAHs.<h4>Results</h4>Treatment2022-01-01T00:00:00Z2022 Jun2026-06-03T10:19:06.403Z2025-02-19T03:22:28.064ZS-EPMC92191523573958410.1186/s12989-022-00482-x