biostudies-literatureZhao NCanadian Institutes of Health ResearchCIHR151https://www.ebi.ac.uk/biostudies/studies/S-EPMC9219240biostudies-literatureUnknown24(1)<h4>Objectives</h4>To estimate associations between fine particulate matter (PM_2.5) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs).<h4>Methods</h4>An open cohort of over 6 million adults was constructed from provincial physician billing and hospitalization records between 2000 and 2013. We defined incident SARD cases (SLE, Sjogren's syndrome, scleroderma, polymyositis, dermatomyositis, polyarteritis nodosa and related conditions, polymyalgia rheumatic, other necrotizing vasculopathies, and undifferentiated connective tissue disease) based on at least two relevant billing diagnostic codes (within 2 years, with at least 1 billing from a rheumatologist), or at least one relevant hospitalization diagnostic code. Estimated PM_2.5 and ozone concentArthritis research & therapyLong-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada.PMC9219240PJT-159682Zhao NLaouan-Sidi EABernatsky SGoldberg MSJean SSmargiassi AChen HGamache PfalseLong-term exposure to fine particulate matter and ozone and the onset of systemic autoimmune rheumatic diseases: an open cohort study in Quebec, Canada.<h4>Objectives</h4>To estimate associations between fine particulate matter (PM_2.5) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs).<h4>Methods</h4>An open cohort of over 6 million adults was constructed from provincial physician billing and hospitalization records between 2000 and 2013. We defined incident SARD cases (SLE, Sjogren's syndrome, scleroderma, polymyositis, dermatomyositis, polyarteritis nodosa and related conditions, polymyalgia rheumatic, other necrotizing vasculopathies, and undifferentiated connective tissue disease) based on at least two relevant billing diagnostic codes (within 2 years, with at least 1 billing from a rheumatologist), or at least one relevant hospitalization diagnostic code. Estimated PM_2.5 and ozone concent2022-01-01T00:00:00Z2022 Jun2025-04-04T11:29:10.493Z2024-11-06T21:04:26.062ZS-EPMC92192403573957810.1186/s13075-022-02843-5