biostudies-literatureD'Alessandro RFondazione Cariplo1041https://www.ebi.ac.uk/biostudies/studies/S-EPMC9219710biostudies-literatureUnknown11(6)Cultivated cardoon (<i>Cynara cardunculus</i> L. var <i>altilis</i>) is a Mediterranean traditional food crop. It is adapted to xerothermic conditions and also grows in marginal lands, producing a large biomass rich in phenolic bioactive metabolites and has therefore received attention for pharmaceutical, cosmetic and innovative materials applications. Cardoon cell cultures can be used for the biotechnological production of valuable molecules in accordance with the principles of cellular agriculture. In the current study, we developed an elicitation strategy on leaf-derived cardoon calli for boosting the production of bioactive extracts for cosmetics. We tested elicitation conditions that trigger hyper-accumulation of bioactive phenolic metabolites without compromising calli growth throughAntioxidants (Basel, Switzerland)Abiotic Stresses Elicitation Potentiates the Productiveness of Cardoon Calli as Bio-Factories for Specialized Metabolites Production.PMC92197102018-0955(2018-0955)Tucci MD'Alessandro RGraziani GDocimo TDe Palma MCappetta ED'Amelia VfalseAbiotic Stresses Elicitation Potentiates the Productiveness of Cardoon Calli as Bio-Factories for Specialized Metabolites Production.Cultivated cardoon (<i>Cynara cardunculus</i> L. var <i>altilis</i>) is a Mediterranean traditional food crop. It is adapted to xerothermic conditions and also grows in marginal lands, producing a large biomass rich in phenolic bioactive metabolites and has therefore received attention for pharmaceutical, cosmetic and innovative materials applications. Cardoon cell cultures can be used for the biotechnological production of valuable molecules in accordance with the principles of cellular agriculture. In the current study, we developed an elicitation strategy on leaf-derived cardoon calli for boosting the production of bioactive extracts for cosmetics. We tested elicitation conditions that trigger hyper-accumulation of bioactive phenolic metabolites without compromising calli growth through2022-01-01T00:00:00Z2022 May2026-05-06T03:09:12.146Z2025-05-18T12:05:06.078ZS-EPMC92197103573993810.3390/antiox11061041