biostudies-literaturePenailillo RANID/CONICYT— FONDECYT RegularANID/CONICYT-FONDECYT PostdoctoradoNICHD/NIH/DHHSANID/CONICYT-FONDECYT de IniciaciónANID/CONICYT—FONDECYT de IniciaciónANID/CONICYT- FONDECYT RegularANID Basal funding for Scientific and Technological Center of Excellence, IMPACTANID/CONICYT—FONDECYT Postdoctorado1253https://www.ebi.ac.uk/biostudies/studies/S-EPMC9219905biostudies-literatureUnknown10(6)Preeclampsia, a disorder with a heterogeneous physiopathology, can be attributed to maternal, fetal, and/or placental factors. Long non-coding RNAs (lncRNAs) refer to a class of non-coding RNAs, the essential regulators of biological processes; their differential expression has been associated with the pathogenesis of multiple diseases. The study aimed to identify lncRNAs, expressed in the placentas and plasma of patients who presented with preeclampsia, as potential putative biomarkers of the disease. In silico analysis was performed to determine lncRNAs differentially expressed in the placentas of patients with preeclampsia, using a previously published RNA-Seq dataset. Seven placentas and maternal plasma samples collected at delivery from preterm preeclamptic patients (≤37 gestational wBiomedicinesIdentification of LOC101927355 as a Novel Biomarker for Preeclampsia.PMC921990511190998HHSN275201300006C31606223140038FB210024111812491201851Velasquez VValdebenito PPAcuna-Gallardo SNardocci GIllanes SEPenailillo RSanchez MDiaz PGarcia FMonteiro LJCorrea PNavarro CRomero RfalseIdentification of LOC101927355 as a Novel Biomarker for Preeclampsia.Preeclampsia, a disorder with a heterogeneous physiopathology, can be attributed to maternal, fetal, and/or placental factors. Long non-coding RNAs (lncRNAs) refer to a class of non-coding RNAs, the essential regulators of biological processes; their differential expression has been associated with the pathogenesis of multiple diseases. The study aimed to identify lncRNAs, expressed in the placentas and plasma of patients who presented with preeclampsia, as potential putative biomarkers of the disease. In silico analysis was performed to determine lncRNAs differentially expressed in the placentas of patients with preeclampsia, using a previously published RNA-Seq dataset. Seven placentas and maternal plasma samples collected at delivery from preterm preeclamptic patients (≤37 gestational w2022-01-01T00:00:00Z2022 May2026-07-14T10:20:48.284Z2025-04-04T11:28:59.932ZS-EPMC92199053574027310.3390/biomedicines10061253