{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ferrer I"],"funding":["La Caixa Foundation","Instituto de Salud Carlos III"],"pagination":["6427"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9223516"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(12)"],"pubmed_abstract":["Altered protein phosphorylation is a major pathologic modification in tauopathies and Alzheimer's disease (AD) linked to abnormal tau fibrillar deposits in neurofibrillary tangles (NFTs) and pre-tangles and β-amyloid deposits in AD. hTau transgenic mice, which express 3R and less 4R human tau with no mutations in a murine knock-out background, show increased tau deposition in neurons but not NFTs and pre-tangles at the age of nine months. Label-free (phospho)proteomics and SWATH-MS identified 2065 proteins in hTau and wild-type (WT) mice. Only six proteins showed increased levels in hTau; no proteins were down-regulated. Increased tau phosphorylation in hTau was detected at Ser199, Ser202, Ser214, Ser396, Ser400, Thr403, Ser404, Ser413, Ser416, Ser422, Ser491, and Ser494, in addition to Th"],"journal":["International journal of molecular sciences"],"pubmed_title":["Dysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model."],"pmcid":["PMC9223516"],"funding_grant_id":["PT17/0019/009","LCF/PR/HR19/52160007"],"pubmed_authors":["Ferrer I","Cartas-Cejudo P","Lachen-Montes M","Del Rio JA","Fernandez-Irigoyen J","Santamaria E","Ausin K","Andres-Benito P"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model.","description":"Altered protein phosphorylation is a major pathologic modification in tauopathies and Alzheimer's disease (AD) linked to abnormal tau fibrillar deposits in neurofibrillary tangles (NFTs) and pre-tangles and β-amyloid deposits in AD. hTau transgenic mice, which express 3R and less 4R human tau with no mutations in a murine knock-out background, show increased tau deposition in neurons but not NFTs and pre-tangles at the age of nine months. Label-free (phospho)proteomics and SWATH-MS identified 2065 proteins in hTau and wild-type (WT) mice. Only six proteins showed increased levels in hTau; no proteins were down-regulated. Increased tau phosphorylation in hTau was detected at Ser199, Ser202, Ser214, Ser396, Ser400, Thr403, Ser404, Ser413, Ser416, Ser422, Ser491, and Ser494, in addition to Th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-04T08:48:11.059Z","creation":"2025-04-04T08:48:11.059Z"},"accession":"S-EPMC9223516","cross_references":{"pubmed":["35742871"],"doi":["10.3390/ijms23126427"]}}