biostudies-literatureJarosz AMedical University of Silesia in KatowiceMedical University of Silesia3504https://www.ebi.ac.uk/biostudies/studies/S-EPMC9224593biostudies-literatureUnknown11(12)<h4>Background</h4>This study aims to identify genotype variants of the platelet-derived growth factor alpha polypeptide gene (<i>PDGFA</i>) that can influence the individual response to the treatment with platelet-rich plasma (PRP) in tennis elbow patients.<h4>Methods</h4>We observed a cohort of 107 patients (132 elbows) with tennis elbow who received treatment with PRP. Patients have been followed-up for two years after PRP injection and the effectiveness of the treatment was measured using universal patient-reported outcome measures (PROMs): visual analog scale (VAS), quick version of disabilities of the arm, shoulder and hand score (QDASH), and patient-rated tennis elbow evaluation (PRTEE). PROMs values, and clinical and platelet parameters were compared between genotype variants of thJournal of clinical medicineWhat Role Does <i>PDGFA</i> Gene Polymorphisms Play in Treating Tennis Elbow with PRP? A Prospective Cohort Study.PMC9224593PCN-1-071/K/0/ZPCN-1-096/K/1/ZBalcerzyk ANegru MGorczynska-Kosiorz SGarczorz WSzyluk KIwanicka JKalita MJarosz AFrancuz TIwanicki TNiemiec PNowak TKania WfalseWhat Role Does <i>PDGFA</i> Gene Polymorphisms Play in Treating Tennis Elbow with PRP? A Prospective Cohort Study.<h4>Background</h4>This study aims to identify genotype variants of the platelet-derived growth factor alpha polypeptide gene (<i>PDGFA</i>) that can influence the individual response to the treatment with platelet-rich plasma (PRP) in tennis elbow patients.<h4>Methods</h4>We observed a cohort of 107 patients (132 elbows) with tennis elbow who received treatment with PRP. Patients have been followed-up for two years after PRP injection and the effectiveness of the treatment was measured using universal patient-reported outcome measures (PROMs): visual analog scale (VAS), quick version of disabilities of the arm, shoulder and hand score (QDASH), and patient-rated tennis elbow evaluation (PRTEE). PROMs values, and clinical and platelet parameters were compared between genotype variants of th2022-01-01T00:00:00Z2022 Jun2026-05-07T03:08:10.468Z2025-02-19T02:58:33.612ZS-EPMC92245933574357310.3390/jcm11123504