{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(6)"],"submitter":["Gill PS"],"pubmed_abstract":["Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, with mutations in hundreds of genes contributing to its risk. Herein, we studied lymphoblastoid cell lines (LCLs) from children diagnosed with autistic disorder (<i>n</i> = 10) and controls (<i>n</i> = 7) using RNA and miRNA sequencing profiles. The sequencing analysis identified 1700 genes and 102 miRNAs differentially expressed between the ASD and control LCLs (<i>p</i> ≤ 0.05). The top upregulated genes were <i>GABRA4</i>, <i>AUTS2</i>, and <i>IL27</i>, and the top upregulated miRNAs were <i>hsa-miR-6813-3p</i>, <i>hsa-miR-221-5p</i>, and <i>hsa-miR-21-5p</i>. The RT-qPCR analysis confirmed the sequencing results for randomly selected candidates: <i>AUTS2</i>, <i>FMR1</i>, <i>PTEN, hsa-miR-15a-5p, hsa-miR-92a-3p</i"],"journal":["Journal of personalized medicine"],"pagination":["920"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9225282"],"repository":["biostudies-literature"],"pubmed_title":["Integrated microRNA-mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism."],"pmcid":["PMC9225282"],"pubmed_authors":["Dweep H","Vyas KK","McCullough S","Gill PS","Wickramasinghe PJ","Rose S","Porter-Gill PA","Frye RE"],"additional_accession":[]},"is_claimable":false,"name":"Integrated microRNA-mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism.","description":"Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, with mutations in hundreds of genes contributing to its risk. Herein, we studied lymphoblastoid cell lines (LCLs) from children diagnosed with autistic disorder (<i>n</i> = 10) and controls (<i>n</i> = 7) using RNA and miRNA sequencing profiles. The sequencing analysis identified 1700 genes and 102 miRNAs differentially expressed between the ASD and control LCLs (<i>p</i> ≤ 0.05). The top upregulated genes were <i>GABRA4</i>, <i>AUTS2</i>, and <i>IL27</i>, and the top upregulated miRNAs were <i>hsa-miR-6813-3p</i>, <i>hsa-miR-221-5p</i>, and <i>hsa-miR-21-5p</i>. The RT-qPCR analysis confirmed the sequencing results for randomly selected candidates: <i>AUTS2</i>, <i>FMR1</i>, <i>PTEN, hsa-miR-15a-5p, hsa-miR-92a-3p</i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-18T13:33:18.974Z","creation":"2025-04-06T23:18:28.137Z"},"accession":"S-EPMC9225282","cross_references":{"pubmed":["35743705"],"doi":["10.3390/jpm12060920"]}}