biostudies-literatureBeck MAstraZenecaFriedrich-Alexander-Universität Erlangen-Nürnberg623-633https://www.ebi.ac.uk/biostudies/studies/S-EPMC9226092biostudies-literatureUnknown36(7)<h4>Aim</h4>In the CheckRad-CD8 trial patients with locally advanced head and neck squamous cell cancer are treated with a single cycle of induction chemo-immunotherapy (ICIT). Patients with pathological complete response (pCR) in the re-biopsy enter radioimmunotherapy. Our goal was to study the value of F-18-FDG PET/CT in the prediction of pCR after induction therapy.<h4>Methods</h4>Patients treated within the CheckRad-CD8 trial that additionally received FDG- PET/CT imaging at the following two time points were included: 3-14 days before (pre-ICIT) and 21-28 days after (post-ICIT) receiving ICIT. Tracer uptake in primary tumors (PT) and suspicious cervical lymph nodes (LN +) was measured using different quantitative parameters on EANM Research Ltd (EARL) accredited PET reconstructions. IAnnals of nuclear medicineF18-FDG PET/CT imaging early predicts pathologic complete response to induction chemoimmunotherapy of locally advanced head and neck cancer: preliminary single-center analysis of the checkrad-cd8 trial.PMC9226092ESR-16-12356Hecht MKlautke GBeck MMuller SKuwert THartwich JHartmann ASchmidt DGaipl USHautmann MGvon der Grun JBrunner TRutzner SDoscher JIllmer TIro HFietkau RSemrau SEckstein MTamaskovics BGostian AOfalseF18-FDG PET/CT imaging early predicts pathologic complete response to induction chemoimmunotherapy of locally advanced head and neck cancer: preliminary single-center analysis of the checkrad-cd8 trial.<h4>Aim</h4>In the CheckRad-CD8 trial patients with locally advanced head and neck squamous cell cancer are treated with a single cycle of induction chemo-immunotherapy (ICIT). Patients with pathological complete response (pCR) in the re-biopsy enter radioimmunotherapy. Our goal was to study the value of F-18-FDG PET/CT in the prediction of pCR after induction therapy.<h4>Methods</h4>Patients treated within the CheckRad-CD8 trial that additionally received FDG- PET/CT imaging at the following two time points were included: 3-14 days before (pre-ICIT) and 21-28 days after (post-ICIT) receiving ICIT. Tracer uptake in primary tumors (PT) and suspicious cervical lymph nodes (LN +) was measured using different quantitative parameters on EANM Research Ltd (EARL) accredited PET reconstructions. I2022-01-01T00:00:00Z2022 Jul2025-06-01T02:05:23.257Z2025-06-01T02:05:23.257ZS-EPMC92260923553469010.1007/s12149-022-01744-6