biostudies-literatureUnknown14(6)de Miguel-Diez J(1) Background: We aimed to assess the effect of COPD in the incidence of hospital admissions for COVID-19 and on the in-hospital mortality (IHM) according to sex. (2) Methods: We used national hospital discharge data to select persons aged ≥40 years admitted to a hospital with a diagnosis of COVID-19 in 2020 in Spain. (3) Results: The study population included 218,301 patients. Age-adjusted incidence rates of COVID-19 hospitalizations for men with and without COPD were 10.66 and 9.27 per 1000 persons, respectively (IRR 1.14; 95% CI 1.08-1.20; <i>p</i> &lt; 0.001). The IHM was higher in men than in women regardless of the history of COPD. The COPD was associated with higher IHM among women (OR 1.09; 95% CI 1.01-1.22) but not among men. The COPD men had a 25% higher risk of dying in the hosViruses1238https://www.ebi.ac.uk/biostudies/studies/S-EPMC9229343biostudies-literatureSex Differences in COVID-19 Hospitalization and Hospital Mortality among Patients with COPD in Spain: A Retrospective Cohort Study.PMC9229343Hernandez-Barrera Vde Miguel-Diez JCarabantes-Alarcon DOmana-Palanco RLopez-de-Andres AJimenez-Garcia RZamorano-Leon JJde Miguel-Yanes JMLopez-Herranz MfalseSex Differences in COVID-19 Hospitalization and Hospital Mortality among Patients with COPD in Spain: A Retrospective Cohort Study.(1) Background: We aimed to assess the effect of COPD in the incidence of hospital admissions for COVID-19 and on the in-hospital mortality (IHM) according to sex. (2) Methods: We used national hospital discharge data to select persons aged ≥40 years admitted to a hospital with a diagnosis of COVID-19 in 2020 in Spain. (3) Results: The study population included 218,301 patients. Age-adjusted incidence rates of COVID-19 hospitalizations for men with and without COPD were 10.66 and 9.27 per 1000 persons, respectively (IRR 1.14; 95% CI 1.08-1.20; <i>p</i> &lt; 0.001). The IHM was higher in men than in women regardless of the history of COPD. The COPD was associated with higher IHM among women (OR 1.09; 95% CI 1.01-1.22) but not among men. The COPD men had a 25% higher risk of dying in the hos2022-01-01T00:00:00Z2022 Jun2025-05-18T12:47:06.731Z2025-05-18T12:47:06.731ZS-EPMC92293433574670910.3390/v14061238