{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ulrich J"],"funding":["This work was in part supported by the Academic Center for Complementary and Integrative Medicine (AZKIM), Project KIG-BaWü, Ministerium für Soziales und Integration Baden-Württemberg, Germany"],"pagination":["3903"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9229828"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(12)"],"pubmed_abstract":["Oleogum resins of the genus <i>Commiphora</i> have been used in traditional medicines for centuries. More than 200 <i>Commiphora</i> species exhibit highly variable phytochemical compositions. A novel highly selective, sensitive, accurate HPLC-MS/MS method was developed and validated to quantify five characteristic phytosteroids and furanosesquiterpenoids, namely (<i>E</i>)-guggulsterone, (<i>Z</i>)-guggulsterone, curzerenone, furanoeudesma-1,3-diene, and myrrhone. The resulting contents and additionally GC analysis were used to classify and differentiate <i>Commiphora</i> oleogum resins of the species <i>C. myrrha</i>, <i>C. erythraea</i>, <i>C. mukul</i>, <i>C. holtziana</i>, <i>C. confusa</i>, and <i>C. kua</i>, as well as unspecified resins. Interestingly, a <i>Commiphora</i> sample fr"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Phytochemical Composition of <i>Commiphora</i> Oleogum Resins and Their Cytotoxicity against Skin Cancer Cells."],"pmcid":["PMC9229828"],"funding_grant_id":["N/A"],"pubmed_authors":["Schmiech M","El Gaafary M","Stiltz S","Simmet T","Syrovets T","St-Gelais A","Ulrich J"],"additional_accession":[]},"is_claimable":false,"name":"Phytochemical Composition of <i>Commiphora</i> Oleogum Resins and Their Cytotoxicity against Skin Cancer Cells.","description":"Oleogum resins of the genus <i>Commiphora</i> have been used in traditional medicines for centuries. More than 200 <i>Commiphora</i> species exhibit highly variable phytochemical compositions. A novel highly selective, sensitive, accurate HPLC-MS/MS method was developed and validated to quantify five characteristic phytosteroids and furanosesquiterpenoids, namely (<i>E</i>)-guggulsterone, (<i>Z</i>)-guggulsterone, curzerenone, furanoeudesma-1,3-diene, and myrrhone. The resulting contents and additionally GC analysis were used to classify and differentiate <i>Commiphora</i> oleogum resins of the species <i>C. myrrha</i>, <i>C. erythraea</i>, <i>C. mukul</i>, <i>C. holtziana</i>, <i>C. confusa</i>, and <i>C. kua</i>, as well as unspecified resins. Interestingly, a <i>Commiphora</i> sample fr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-03T22:54:08.248Z","creation":"2024-10-16T17:32:09.99Z"},"accession":"S-EPMC9229828","cross_references":{"pubmed":["35745024"],"doi":["10.3390/molecules27123903"]}}