biostudies-literatureUlrich JThis work was in part supported by the Academic Center for Complementary and Integrative Medicine (AZKIM), Project KIG-BaWü, Ministerium für Soziales und Integration Baden-Württemberg, Germany3903https://www.ebi.ac.uk/biostudies/studies/S-EPMC9229828biostudies-literatureUnknown27(12)Oleogum resins of the genus <i>Commiphora</i> have been used in traditional medicines for centuries. More than 200 <i>Commiphora</i> species exhibit highly variable phytochemical compositions. A novel highly selective, sensitive, accurate HPLC-MS/MS method was developed and validated to quantify five characteristic phytosteroids and furanosesquiterpenoids, namely (<i>E</i>)-guggulsterone, (<i>Z</i>)-guggulsterone, curzerenone, furanoeudesma-1,3-diene, and myrrhone. The resulting contents and additionally GC analysis were used to classify and differentiate <i>Commiphora</i> oleogum resins of the species <i>C. myrrha</i>, <i>C. erythraea</i>, <i>C. mukul</i>, <i>C. holtziana</i>, <i>C. confusa</i>, and <i>C. kua</i>, as well as unspecified resins. Interestingly, a <i>Commiphora</i> sample frMolecules (Basel, Switzerland)Phytochemical Composition of <i>Commiphora</i> Oleogum Resins and Their Cytotoxicity against Skin Cancer Cells.PMC9229828N/ASchmiech MEl Gaafary MStiltz SSimmet TSyrovets TSt-Gelais AUlrich JfalsePhytochemical Composition of <i>Commiphora</i> Oleogum Resins and Their Cytotoxicity against Skin Cancer Cells.Oleogum resins of the genus <i>Commiphora</i> have been used in traditional medicines for centuries. More than 200 <i>Commiphora</i> species exhibit highly variable phytochemical compositions. A novel highly selective, sensitive, accurate HPLC-MS/MS method was developed and validated to quantify five characteristic phytosteroids and furanosesquiterpenoids, namely (<i>E</i>)-guggulsterone, (<i>Z</i>)-guggulsterone, curzerenone, furanoeudesma-1,3-diene, and myrrhone. The resulting contents and additionally GC analysis were used to classify and differentiate <i>Commiphora</i> oleogum resins of the species <i>C. myrrha</i>, <i>C. erythraea</i>, <i>C. mukul</i>, <i>C. holtziana</i>, <i>C. confusa</i>, and <i>C. kua</i>, as well as unspecified resins. Interestingly, a <i>Commiphora</i> sample fr2022-01-01T00:00:00Z2022 Jun2025-04-03T22:54:08.248Z2024-10-16T17:32:09.99ZS-EPMC92298283574502410.3390/molecules27123903