biostudies-literatureStanasila LSwiss National Science FoundationGlaxoSmithKlineFaculty of Biology and Medicine of Lausanne2500https://www.ebi.ac.uk/biostudies/studies/S-EPMC9229848biostudies-literatureUnknown14(12)<h4>Background</h4>The association between inflammation and dietary sterols remains poorly assessed at the population level.<h4>Aims</h4>To assess the possible association between serum levels of various phytosterols (PS) and inflammatory markers.<h4>Methods</h4>Serum levels of six PS (campesterol, campestanol, stigmasterol, sitosterol, sitostanol, brassicasterol), four cholesterol synthesis markers (lathosterol, lanosterol, desmosterol, dihydroxylanosterol) and one cholesterol absorption marker (cholestanol) were measured together with levels of CRP, IL-6 and TNF-α in two cross-sectional surveys of a population-based, prospective study.<h4>Results</h4>CRP levels were negatively associated with levels of cholestanol and of sterols of plant origin, although some associations were not statisNutrientsSerum Phytosterols Are Not Associated with Inflammatory Markers in Two Cross-Sectional, Swiss Population-Based Studies (The CoLaus|PsyCoLaus Study).PMC9229848no number3200B0-105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468, 33CS30-148401 and 33CS30_177535/11059933200B0–105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468, 33CS30-148401 and 33CS30_177535/1118308Stanasila LMarques-Vidal PfalseSerum Phytosterols Are Not Associated with Inflammatory Markers in Two Cross-Sectional, Swiss Population-Based Studies (The CoLaus|PsyCoLaus Study).<h4>Background</h4>The association between inflammation and dietary sterols remains poorly assessed at the population level.<h4>Aims</h4>To assess the possible association between serum levels of various phytosterols (PS) and inflammatory markers.<h4>Methods</h4>Serum levels of six PS (campesterol, campestanol, stigmasterol, sitosterol, sitostanol, brassicasterol), four cholesterol synthesis markers (lathosterol, lanosterol, desmosterol, dihydroxylanosterol) and one cholesterol absorption marker (cholestanol) were measured together with levels of CRP, IL-6 and TNF-α in two cross-sectional surveys of a population-based, prospective study.<h4>Results</h4>CRP levels were negatively associated with levels of cholestanol and of sterols of plant origin, although some associations were not statis2022-01-01T00:00:00Z2022 Jun2025-04-04T19:06:28.215Z2025-04-04T19:06:28.215ZS-EPMC92298483574523210.3390/nu14122500