biostudies-literatureLyu TNCATS NIH HHSNIMH NIH HHSNCI NIH HHS615-633https://www.ebi.ac.uk/biostudies/studies/S-EPMC9232183biostudies-literatureUnknown19(4)Regression methods, including the proportional rates model and additive rates model, have been proposed to evaluate the effect of covariates on the risk of recurrent events. These two models have different assumptions on the form of the covariate effects. A more flexible model, the additive-multiplicative rates model, is considered to allow the covariates to have both additive and multiplicative effects on the marginal rate of recurrent event process. However, its use is limited to the cases where the time-dependent covariates are monitored continuously throughout the follow-up time. In practice, time-dependent covariates are often only measured intermittently, which renders the current estimation method for the additive-multiplicative rates model inapplicable. In this paper, we propose a Journal of data science : JDSAdditive-Multiplicative Rates Model for Recurrent Event Data with Intermittently Observed Time-Dependent Covariates.PMC9232183R03 MH112895P30 CA077598UL1 TR000114Lyu TLuo XSun YfalseAdditive-Multiplicative Rates Model for Recurrent Event Data with Intermittently Observed Time-Dependent Covariates.Regression methods, including the proportional rates model and additive rates model, have been proposed to evaluate the effect of covariates on the risk of recurrent events. These two models have different assumptions on the form of the covariate effects. A more flexible model, the additive-multiplicative rates model, is considered to allow the covariates to have both additive and multiplicative effects on the marginal rate of recurrent event process. However, its use is limited to the cases where the time-dependent covariates are monitored continuously throughout the follow-up time. In practice, time-dependent covariates are often only measured intermittently, which renders the current estimation method for the additive-multiplicative rates model inapplicable. In this paper, we propose a 2021-01-01T00:00:00Z2021 Oct2025-04-26T20:44:03.67Z2025-04-06T16:34:53.545ZS-EPMC92321833575719910.6339/21-jds1027