{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Denfeld QE"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","NINR NIH HHS","National Institutes of Health"],"pagination":["973-981"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9232872"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(6)"],"pubmed_abstract":["<h4>Background</h4>Symptoms, which often cluster together, are a significant problem in heart failure (HF). There is considerable heterogeneity in symptom burden, particularly in the vulnerable transition period after a hospitalization for HF, and the biological underpinnings of symptoms during transitions are unclear. The purpose of this article is to describe the background and design of a study that addresses these knowledge gaps, entitled Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF).<h4>Methods and results</h4>BIOMES-HF is a prospective gender- and age-balanced longitudinal study of 240 adults during the 6-month transition period after a HF hospitalization. The aims are to (1) identify clusters of change in physical symptoms, (2) quantify lon"],"journal":["Journal of cardiac failure"],"pubmed_title":["Background and Design of the Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF) Study."],"pmcid":["PMC9232872"],"funding_grant_id":["UL1TR002369","UL1 TR002369","R01 NR019054"],"pubmed_authors":["Roberts Davis M","Dieckmann N","Cramer DV","Rupert A","Denfeld QE","Camacho SA","Lee CS","Hiatt SO","Habecker BA"],"additional_accession":[]},"is_claimable":false,"name":"Background and Design of the Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF) Study.","description":"<h4>Background</h4>Symptoms, which often cluster together, are a significant problem in heart failure (HF). There is considerable heterogeneity in symptom burden, particularly in the vulnerable transition period after a hospitalization for HF, and the biological underpinnings of symptoms during transitions are unclear. The purpose of this article is to describe the background and design of a study that addresses these knowledge gaps, entitled Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF).<h4>Methods and results</h4>BIOMES-HF is a prospective gender- and age-balanced longitudinal study of 240 adults during the 6-month transition period after a HF hospitalization. The aims are to (1) identify clusters of change in physical symptoms, (2) quantify lon","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-19T23:05:19.758Z","creation":"2025-04-19T23:05:19.758Z"},"accession":"S-EPMC9232872","cross_references":{"pubmed":["35045322"],"doi":["10.1016/j.cardfail.2022.01.003"]}}