biostudies-literatureDenfeld QENational Center for Advancing Translational SciencesNCATS NIH HHSNINR NIH HHSNational Institutes of Health973-981https://www.ebi.ac.uk/biostudies/studies/S-EPMC9232872biostudies-literatureUnknown28(6)<h4>Background</h4>Symptoms, which often cluster together, are a significant problem in heart failure (HF). There is considerable heterogeneity in symptom burden, particularly in the vulnerable transition period after a hospitalization for HF, and the biological underpinnings of symptoms during transitions are unclear. The purpose of this article is to describe the background and design of a study that addresses these knowledge gaps, entitled Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF).<h4>Methods and results</h4>BIOMES-HF is a prospective gender- and age-balanced longitudinal study of 240 adults during the 6-month transition period after a HF hospitalization. The aims are to (1) identify clusters of change in physical symptoms, (2) quantify lonJournal of cardiac failureBackground and Design of the Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF) Study.PMC9232872UL1TR002369UL1 TR002369R01 NR019054Roberts Davis MDieckmann NCramer DVRupert ADenfeld QECamacho SALee CSHiatt SOHabecker BAfalseBackground and Design of the Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF) Study.<h4>Background</h4>Symptoms, which often cluster together, are a significant problem in heart failure (HF). There is considerable heterogeneity in symptom burden, particularly in the vulnerable transition period after a hospitalization for HF, and the biological underpinnings of symptoms during transitions are unclear. The purpose of this article is to describe the background and design of a study that addresses these knowledge gaps, entitled Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF).<h4>Methods and results</h4>BIOMES-HF is a prospective gender- and age-balanced longitudinal study of 240 adults during the 6-month transition period after a HF hospitalization. The aims are to (1) identify clusters of change in physical symptoms, (2) quantify lon2022-01-01T00:00:00Z2022 Jun2025-04-19T23:05:19.758Z2025-04-19T23:05:19.758ZS-EPMC92328723504532210.1016/j.cardfail.2022.01.003