biostudies-literatureUnknown23(1)Peng LJ<h4>Background</h4>T cell acute lymphoblastic leukemia (T-ALL) defines a group of hematological malignancies with heterogeneous aggressiveness and highly variable outcome, making therapeutic decisions a challenging task. We tried to discover new predictive model for T-ALL before treatment by using a specific pipeline designed to discover aberrantly active gene.<h4>Results</h4>The expression of 18 genes was significantly associated with shorter survival, including ACTRT2, GOT1L1, SPATA45, TOPAZ1 and ZPBP (5-GEC), which were used as a basis to design a prognostic classifier for T-ALL patients. The molecular characterization of the 5-GEC positive T-ALL unveiled specific characteristics inherent to the most aggressive T leukemic cells, including a drastic shut-down of genes located on the mitoBMC genomics467https://www.ebi.ac.uk/biostudies/studies/S-EPMC9233359biostudies-literatureEctopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia.PMC9233359Zhang JJMi JQBourova-Flin EKhochbin SCheng ZYChen BWang JGeng MZhou YBRousseaux SWang TLiu YFPeng LJXi MPChuffart FZhang WNGao MQfalseEctopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia.<h4>Background</h4>T cell acute lymphoblastic leukemia (T-ALL) defines a group of hematological malignancies with heterogeneous aggressiveness and highly variable outcome, making therapeutic decisions a challenging task. We tried to discover new predictive model for T-ALL before treatment by using a specific pipeline designed to discover aberrantly active gene.<h4>Results</h4>The expression of 18 genes was significantly associated with shorter survival, including ACTRT2, GOT1L1, SPATA45, TOPAZ1 and ZPBP (5-GEC), which were used as a basis to design a prognostic classifier for T-ALL patients. The molecular characterization of the 5-GEC positive T-ALL unveiled specific characteristics inherent to the most aggressive T leukemic cells, including a drastic shut-down of genes located on the mito2022-01-01T00:00:00Z2022 Jun2026-05-29T01:07:01.146Z2024-11-20T17:23:38.532ZS-EPMC92333593575101610.1186/s12864-022-08688-1