{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21"],"submitter":["Kitamura M"],"pubmed_abstract":["<h4>Introduction</h4>Currently, flap operation (FOP) using REGROTH® (0.3% basic fibroblast growth factor [FGF-2]) is the standard treatment for periodontal regenerative therapy in Japan. However, the periodontal tissue regenerative effect with REGROTH® monotherapy is inadequate for severe alveolar bone defects. Therefore, in this study, we evaluated the safety and effectiveness of periodontal regenerative therapy for patients with severe periodontitis using REGROTH® (test medicine) combined with Cytrans® Granules (test device: carbonated apatite granules), which is a new artificial bone.<h4>Methods</h4>The study participants included 10 patients with severe periodontitis (mean age: 47.4 years). All participants provided written informed consents. In each patient, the intrabony defect site "],"journal":["Regenerative therapy"],"pagination":["104-113"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9234541"],"repository":["biostudies-literature"],"pubmed_title":["An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH® and Cytrans® granules for severe periodontitis with intrabony defects."],"pmcid":["PMC9234541"],"pubmed_authors":["Kashiwagi Y","Yamanaka K","Takedachi M","Ikegami K","Ishihara Y","Masuda H","Miki K","Murakami S","Nozaki T","Kitamura M","Yamashita M"],"additional_accession":[]},"is_claimable":false,"name":"An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH® and Cytrans® granules for severe periodontitis with intrabony defects.","description":"<h4>Introduction</h4>Currently, flap operation (FOP) using REGROTH® (0.3% basic fibroblast growth factor [FGF-2]) is the standard treatment for periodontal regenerative therapy in Japan. However, the periodontal tissue regenerative effect with REGROTH® monotherapy is inadequate for severe alveolar bone defects. Therefore, in this study, we evaluated the safety and effectiveness of periodontal regenerative therapy for patients with severe periodontitis using REGROTH® (test medicine) combined with Cytrans® Granules (test device: carbonated apatite granules), which is a new artificial bone.<h4>Methods</h4>The study participants included 10 patients with severe periodontitis (mean age: 47.4 years). All participants provided written informed consents. In each patient, the intrabony defect site ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T11:59:11.296Z","creation":"2022-07-10T04:26:46.406Z"},"accession":"S-EPMC9234541","cross_references":{"pubmed":["35785043"],"doi":["10.1016/j.reth.2022.06.001"]}}