biostudies-literatureUnknown10(12)Kumagai HThis study aimed to assess (1) blood pressure between young, current athletes, and non-athletes early in life; (2) hypertension prevalence between former athletes and the general population later in life; and (3) understand the mechanisms between exercise training and hypertension risks in the form of DNA methylation. Study 1: A total of 354 young male participants, including current athletes, underwent blood pressure assessment. Study 2: The prevalence of hypertension in 1269 male former athletes was compared with that in the Japanese general population. Current and former athletes were divided into three groups: endurance-, mixed-, and sprint/power-group. Study 3: We analyzed the effect of aerobic- or resistance-training on DNA methylation patterns using publicly available datasets to exPhysiological reportse15364https://www.ebi.ac.uk/biostudies/studies/S-EPMC9234749biostudies-literatureSports activities at a young age decrease hypertension risk-The J-Fit⁺ study.PMC9234749Kumagai HMaeda SSomeya YKohmura YYoshioka MSuzuki KTagawa KFuku NNaito HKumagai MEKidokoro TChoi YMiyamoto-Mikami EMiller BMachida SfalseSports activities at a young age decrease hypertension risk-The J-Fit⁺ study.This study aimed to assess (1) blood pressure between young, current athletes, and non-athletes early in life; (2) hypertension prevalence between former athletes and the general population later in life; and (3) understand the mechanisms between exercise training and hypertension risks in the form of DNA methylation. Study 1: A total of 354 young male participants, including current athletes, underwent blood pressure assessment. Study 2: The prevalence of hypertension in 1269 male former athletes was compared with that in the Japanese general population. Current and former athletes were divided into three groups: endurance-, mixed-, and sprint/power-group. Study 3: We analyzed the effect of aerobic- or resistance-training on DNA methylation patterns using publicly available datasets to ex2022-01-01T00:00:00Z2022 Jun2025-04-04T22:16:30.791Z2022-07-10T02:02:04.986ZS-EPMC92347493575790310.14814/phy2.15364