{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Qin Y"],"pubmed_abstract":["Flavonoids were the major phytochemicals against hepatic peroxidative injury in <i>Scleromitron diffusum</i> (Willd.) R. J. Wang with an inventive bio-enzymatic method by our group (LU500041). Firstly, the total flavonoids from <i>Scleromitron diffusum</i> (Willd.) R. J. Wang were extracted by reflux, ultrasonic, ultrasound-assisted enzymatic methods (TFH), and the bio-enzymatic method (Ey-TFH). Then 24 flavonoid compounds were isolated and quantified in the extracts by UPLC-MS/MS. Next, six representative differential compounds in Ey-TFH were further screened out by multivariate statistical analysis compared with those in TFH. In a further step, Ey-TFH presented a higher protective rate (59.30 ± 0.81%) against H<sub>2</sub>O<sub>2</sub>-damaged HL-02 hepatocytes than TFH. And six represen"],"journal":["Frontiers in pharmacology"],"pagination":["890148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9234865"],"repository":["biostudies-literature"],"pubmed_title":["Isolation and Quantification of the Hepatoprotective Flavonoids From <i>Scleromitron diffusum</i> (Willd.) R. J. Wang With Bio-Enzymatic Method Against NAFLD by UPLC-MS/MS."],"pmcid":["PMC9234865"],"pubmed_authors":["Qiao Y","Li Y","Zhao B","Shi C","Qin Y","Liu Q","Zhang M","Deng H"],"additional_accession":[]},"is_claimable":false,"name":"Isolation and Quantification of the Hepatoprotective Flavonoids From <i>Scleromitron diffusum</i> (Willd.) R. J. Wang With Bio-Enzymatic Method Against NAFLD by UPLC-MS/MS.","description":"Flavonoids were the major phytochemicals against hepatic peroxidative injury in <i>Scleromitron diffusum</i> (Willd.) R. J. Wang with an inventive bio-enzymatic method by our group (LU500041). Firstly, the total flavonoids from <i>Scleromitron diffusum</i> (Willd.) R. J. Wang were extracted by reflux, ultrasonic, ultrasound-assisted enzymatic methods (TFH), and the bio-enzymatic method (Ey-TFH). Then 24 flavonoid compounds were isolated and quantified in the extracts by UPLC-MS/MS. Next, six representative differential compounds in Ey-TFH were further screened out by multivariate statistical analysis compared with those in TFH. In a further step, Ey-TFH presented a higher protective rate (59.30 ± 0.81%) against H<sub>2</sub>O<sub>2</sub>-damaged HL-02 hepatocytes than TFH. And six represen","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T11:28:31.209Z","creation":"2025-04-04T11:28:31.209Z"},"accession":"S-EPMC9234865","cross_references":{"pubmed":["35770080"],"doi":["10.3389/fphar.2022.890148"]}}