{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(1)"],"submitter":["Cheng B"],"pubmed_abstract":["<h4>Background</h4>Hepatitis B virus can induce hepatocellular carcinoma (HCC) by inducing a host immune response against infected hepatocytes. C-terminally truncated middle surface protein (MHBSt) has been reported to contribute to HCC through transcriptional activation in epidemiology studies, while the underlying mechanism of MHBSt-induced HCC is unknown.<h4>Methods</h4>In this study, a premature stop at codon 167 in MHBS (MHBSt<sup>167</sup>) was investigated into eukaryotic expression plasmid pcDNA3.1(-). MHBSt<sup>167</sup> expressed plasmid was transfected into the L02 cell line, cell proliferation was analyzed by CCK-8 and high-content screening assays, the cell cycle was analyzed by flow cytometry, and epithelial-to-mesenchymal transition and autophagy were analyzed by immunoblott"],"journal":["Virology journal"],"pagination":["110"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9235077"],"repository":["biostudies-literature"],"pubmed_title":["MHBSt<sup>167</sup> induced autophagy promote cell proliferation and EMT by activating the immune response in L02 cells."],"pmcid":["PMC9235077"],"pubmed_authors":["Zeng S","Wang Q","He Y","Cheng B","Li R","Wei Z","Meng Z","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"MHBSt<sup>167</sup> induced autophagy promote cell proliferation and EMT by activating the immune response in L02 cells.","description":"<h4>Background</h4>Hepatitis B virus can induce hepatocellular carcinoma (HCC) by inducing a host immune response against infected hepatocytes. C-terminally truncated middle surface protein (MHBSt) has been reported to contribute to HCC through transcriptional activation in epidemiology studies, while the underlying mechanism of MHBSt-induced HCC is unknown.<h4>Methods</h4>In this study, a premature stop at codon 167 in MHBS (MHBSt<sup>167</sup>) was investigated into eukaryotic expression plasmid pcDNA3.1(-). MHBSt<sup>167</sup> expressed plasmid was transfected into the L02 cell line, cell proliferation was analyzed by CCK-8 and high-content screening assays, the cell cycle was analyzed by flow cytometry, and epithelial-to-mesenchymal transition and autophagy were analyzed by immunoblott","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-22T11:49:50.535Z","creation":"2025-04-06T00:08:35.709Z"},"accession":"S-EPMC9235077","cross_references":{"pubmed":["35761331"],"doi":["10.1186/s12985-022-01840-z"]}}