{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Luo Y"],"pubmed_abstract":["<h4>Purpose</h4>We previously reported that G protein-coupled receptor kinase (GRK) 4 halts cell cycle progression and induces cellular senescence in HEK293 cells. The present study was aimed at assessing the prognostic value of GRK4 in hepatocellular carcinoma (HCC).<h4>Methods</h4>GRK4 expression was detected by immunohistochemistry in paired tumoral and peritumoral tissues of 325 HCC patients. One hundred and twenty-six patients from Western China were utilized as a training cohort to develop a nomogram, while 86 patients from Eastern China were used as a validation cohort. The proliferation and migration of lentiviral-GRK4 expressing HepG2 cells were determined by MTT and wound healing assays.<h4>Results</h4>GRK4 was differentially expressed in HCC tissues. Tumoral GRK4 intensity, tumo"],"journal":["Disease markers"],"pagination":["2628879"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9236775"],"repository":["biostudies-literature"],"pubmed_title":["G Protein-Coupled Receptor Kinase 4 Is a Novel Prognostic Factor in Hepatocellular Carcinoma."],"pmcid":["PMC9236775"],"pubmed_authors":["Jiang X","Luo Y","Li R","Wang Z","Xiao S"],"additional_accession":[]},"is_claimable":false,"name":"G Protein-Coupled Receptor Kinase 4 Is a Novel Prognostic Factor in Hepatocellular Carcinoma.","description":"<h4>Purpose</h4>We previously reported that G protein-coupled receptor kinase (GRK) 4 halts cell cycle progression and induces cellular senescence in HEK293 cells. The present study was aimed at assessing the prognostic value of GRK4 in hepatocellular carcinoma (HCC).<h4>Methods</h4>GRK4 expression was detected by immunohistochemistry in paired tumoral and peritumoral tissues of 325 HCC patients. One hundred and twenty-six patients from Western China were utilized as a training cohort to develop a nomogram, while 86 patients from Eastern China were used as a validation cohort. The proliferation and migration of lentiviral-GRK4 expressing HepG2 cells were determined by MTT and wound healing assays.<h4>Results</h4>GRK4 was differentially expressed in HCC tissues. Tumoral GRK4 intensity, tumo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-21T14:20:52.408Z","creation":"2025-04-21T14:20:52.408Z"},"accession":"S-EPMC9236775","cross_references":{"pubmed":["35769816"],"doi":["10.1155/2022/2628879"]}}