biostudies-literatureMadde ANHLBINHLBI NIH HHSNational Institutes of Health769-776https://www.ebi.ac.uk/biostudies/studies/S-EPMC9237179biostudies-literatureUnknown21(5)<h4>Background</h4>There is a strong association between nutrition and long-term FEV1 in cystic fibrosis (CF), but studies have been driven by data from subjects with pancreatic insufficiency (PI-CF). We thus evaluated the association between body mass index (BMI) and FEV1 percent-predicted (FEV1pp) in children with pancreatic sufficiency (PS-CF) and contrasted it with the association in PI-CF.<h4>Methods</h4>We utilized data from the CF Foundation Patient Registry. The cohort included children born 1995-2010, diagnosed <2 years of age, and who had annualized data on BMI percentile and FEV1pp at ages 6-16 years. Pancreatic status was defined based on pancreatic enzyme replacement therapy. The association between BMI and FEV1 was evaluated using linear and mixed-effects longitudinal regression.<h4>Results</h4>There were 424 children with PS-CF and 7,849 with PI-CF. The association between BMI and FEV1 differed significantly by pancreatic status: each 10-pct higher BMI was associated with 2% [95%CI = 1.9-2.1] higher FEV1pp in PI-CF, compared to just 0.9% [0.5-1.3] in PS-CF (P_INTERACTION < 0.001). Within the at-risk nutritional category (BMI <25pct), each 10-pct higher BMI was associated with 5% higher FEV1pp in PI-CF, but no significant increase in PS-CF. Moreover, in PS-CF, overweight/obesity (BMI ≥85pct) was associated with decreasing FEV1pp. In addition, FEV1pp decline through age 20 years in youth with PS-CF was modest (-0.6% per year) and independent of BMI (BMI*age P_INTERACTION = 0.37).<h4>Conclusions</h4>In children with PS-CF, BMI remains an important determinant of lung function. However, it may be less critical to attain a BMI >50^th percentile; and BMI ≥85^th percentile may be detrimental.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis SocietyNutritional status and lung function in children with pancreatic-sufficient cystic fibrosis.PMC9237179R01 HL149693HL149693Ren CLMadde AForno EOkoniewski WWeiner DJSanders DBfalseNutritional status and lung function in children with pancreatic-sufficient cystic fibrosis.<h4>Background</h4>There is a strong association between nutrition and long-term FEV1 in cystic fibrosis (CF), but studies have been driven by data from subjects with pancreatic insufficiency (PI-CF). We thus evaluated the association between body mass index (BMI) and FEV1 percent-predicted (FEV1pp) in children with pancreatic sufficiency (PS-CF) and contrasted it with the association in PI-CF.<h4>Methods</h4>We utilized data from the CF Foundation Patient Registry. The cohort included children born 1995-2010, diagnosed <2 years of age, and who had annualized data on BMI percentile and FEV1pp at ages 6-16 years. Pancreatic status was defined based on pancreatic enzyme replacement therapy. The association between BMI and FEV1 was evaluated using linear and mixed-effects longitudinal regression.<h4>Results</h4>There were 424 children with PS-CF and 7,849 with PI-CF. The association between BMI and FEV1 differed significantly by pancreatic status: each 10-pct higher BMI was associated with 2% [95%CI = 1.9-2.1] higher FEV1pp in PI-CF, compared to just 0.9% [0.5-1.3] in PS-CF (P_INTERACTION < 0.001). Within the at-risk nutritional category (BMI <25pct), each 10-pct higher BMI was associated with 5% higher FEV1pp in PI-CF, but no significant increase in PS-CF. Moreover, in PS-CF, overweight/obesity (BMI ≥85pct) was associated with decreasing FEV1pp. In addition, FEV1pp decline through age 20 years in youth with PS-CF was modest (-0.6% per year) and independent of BMI (BMI*age P_INTERACTION = 0.37).<h4>Conclusions</h4>In children with PS-CF, BMI remains an important determinant of lung function. However, it may be less critical to attain a BMI >50^th percentile; and BMI ≥85^th percentile may be detrimental.2022-01-01T00:00:00Z2022 Sep2025-04-19T01:29:06.058Z2025-04-07T12:17:20.323ZS-EPMC92371793497265010.1016/j.jcf.2021.12.014