biostudies-literatureVerma ABLRD VANCATS NIH HHSNIDDK NIH HHSNHGRI NIH HHSCSRD VA796-804https://www.ebi.ac.uk/biostudies/studies/S-EPMC9237798biostudies-literatureUnknown182(8)<h4>Importance</h4>Sickle cell trait (SCT), defined as the presence of 1 hemoglobin beta sickle allele (rs334-T) and 1 normal beta allele, is prevalent in millions of people in the US, particularly in individuals of African and Hispanic ancestry. However, the association of SCT with COVID-19 is unclear.<h4>Objective</h4>To assess the association of SCT with the prepandemic health conditions in participants of the Million Veteran Program (MVP) and to assess the severity and sequelae of COVID-19.<h4>Design, setting, and participants</h4>COVID-19 clinical data include 2729 persons with SCT, of whom 353 had COVID-19, and 129 848 SCT-negative individuals, of whom 13 488 had COVID-19. Associations between SCT and COVID-19 outcomes were examined using firth regression. Analyses were performed by JAMA internal medicineAssociation of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait.PMC9237798I01 BX004821IK2 CX001780R01 HG006139UL1 TR001863I01 CX001727U01 DK078616I01 CX001897Wilson PIruvanti PLiao KPWhitbourne SBDamrauer SDGappy SMinnier JWells QSGatsby ELynch JAJhala DChang KMArgyres DPRajeevan NConnor TGutierrez SKinlay SReaven PDAguayo SGodschalk MTsao PMoser JDuVall SLHumphries DEDellitalia LBrewer JVOkusaga OXu JThompson TKHauser ELynch KEChurby LAhuja SDo NGibson GGaddy MHuq MArjomandi MPolimanti RShayan SABallas ZMoorman JRatcliffe NDalal SHung AMHuffman JERobey BMeigs JBWhooley MHarley JLiangpunsakul SLichy JLuoh SWHammer KStapley THauger RLTandon NRoss GMathew RSherman SZhao HServatius RGupta SPathak GAKlein JSriram PGorman BRWilson PWFGreco JJhala DNRamoni RMurdoch MWan ESAssimes TCohen DHo YLIyengar SKHuang GStephens BKaminsky LBeckham JVerma AGelernter JHuang RDLWells JBoyko EZhou JJIvins DVillareal GRoussos PConstans JTsao PSSharma SAslan MMadduri RKMastorides SBrophy MTMeyer LGarcon HWallbom AMeyer PSuzuki ATuteja SGao LJacono FHurley RPetersen JMZekavat SMDonskey CJHung AWhittle JMuralidhar SPyarajan SWu WCVA Million Veteran Program COVID-19 Science InitiativeCho KSun YVThomann LSelva LEYeh SSHamner MFayad JKosik NNatarajan PO'Donnell CJBreeling JStriker RStrollo PBonomo RARauchman MJoseph JMcArdle RFreiberg MSMattocks KFlorez HOursler KAMorgan TBhushan SGaziano JMMcGeary JEfalseAssociation of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait.<h4>Importance</h4>Sickle cell trait (SCT), defined as the presence of 1 hemoglobin beta sickle allele (rs334-T) and 1 normal beta allele, is prevalent in millions of people in the US, particularly in individuals of African and Hispanic ancestry. However, the association of SCT with COVID-19 is unclear.<h4>Objective</h4>To assess the association of SCT with the prepandemic health conditions in participants of the Million Veteran Program (MVP) and to assess the severity and sequelae of COVID-19.<h4>Design, setting, and participants</h4>COVID-19 clinical data include 2729 persons with SCT, of whom 353 had COVID-19, and 129 848 SCT-negative individuals, of whom 13 488 had COVID-19. Associations between SCT and COVID-19 outcomes were examined using firth regression. Analyses were performed by 2022-01-01T00:00:00Z2022 Aug2026-05-28T01:51:09.276Z2024-11-20T17:59:27.906ZS-EPMC92377983575925410.1001/jamainternmed.2022.2141